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Chemical Compound Review

isocitrate     1-hydroxypropane-1,2,3- tricarboxylic acid

Synonyms: I-CIT, D-isocitrate, isocitric acid, CHEMBL539669, AG-K-74513, ...
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Disease relevance of Isocitric acid c

  • Subsequently, the ability of CitM to transport D-isocitrate was demonstrated by competition experiments and by heterologous exchange in right-side-out membrane vesicles prepared from E. coli cells expressing citM [1].

High impact information on Isocitric acid c

  • Similarly, the Km of NAD+-linked isocitrate dehydrogenase for threo-Ds-isocitrate was lower in permeabilized mitochondria than in extracts under all the conditions investigated [2].
  • The oxidative decarboxylation of D-isocitrate catalyzed by NADP-linked isocitrate dehydrogenase is activated by NADPH, the product of the reaction [3].
  • Saturation curves with respect to the substrate threo-DS-isocitrate complexed with the metals including manganous, cadmium, cobaltous and zinc ions showed sigmoid relationships characteristic of allosteric enzymes [4].
  • Aluminum ions (Al3+) acted as a partial competitive inhibitor of the enzyme with respect to the substrate threo-Ds-isocitrate and inhibited the enzyme non-competitively with respect to NADP at pH 6.85 [5].
  • Isocitrate lyase (threo-DS-isocitrate glyoxylate-lyase, EC was isolated from cotyledons of Lupinus seedlings, purified 100-fold with respect to its initial specific activity and characterized (Km, pH optimum, Mg2+ requirement, sulfhydryl inhibitors, and synthase activity) [6].


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