Disease relevance of Drug Administration Schedule

• In addition, age, performance status, bilirubinaemia, genetic polymorphism of uridine 5'-diphosphate-glucuronyltransferase-1A1 and drug administration schedule have been shown to be related to irinotecan toxicity [1].

High impact information on Drug Administration Schedule

• Thus, optimization for the drug administration schedule is important when aiming at therapeutic synergy and circumvention of acquired CDDP resistance [2].
• Using this drug administration schedule, the recommended phase II dose is paclitaxel 150 mg/m2 and gemcitabine 3000 mg/m2 [3].
• Two additional groups were given a discontinuous drug administration schedule with either one or two 24 h drug-free periods interpolated among the 6 or 9 days of phenobarbital consumption, respectively [4].
• Similar drug administration schedules caused increases in AP-1 DNA-binding activity at the 3 h time point in all groups [5].
• Low-dose (5 mg/kg) desferrioxamine treatment in acutely aluminium-intoxicated haemodialysis patients using two drug administration schedules [6].

Associations of Drug Administration Schedule with chemical compounds

• The data suggest, with respect to the drug administration schedules used, that the DAF method was not suitable for the establishment of physical dependence on pentobarbital in mice [7].

Gene context of Drug Administration Schedule

• Physostigmine, an acetylcholinesterase (AChE) inhibitor, alleviated the scopolamine-induced memory impairment in all these drug administration schedules [8].

References