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MeSH Review

Pigmentation Disorders

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Disease relevance of Pigmentation Disorders


High impact information on Pigmentation Disorders


Chemical compound and disease context of Pigmentation Disorders


Anatomical context of Pigmentation Disorders


Gene context of Pigmentation Disorders

  • Phenotypic similarities to some pigmentation disorders in human and mouse, combined with comparative mapping data, identified KIT, encoding the mast cell growth factor receptor, as a major candidate gene for the roan locus (Rn) [11].
  • In the other diseases, the mean values of IgA-CIC (SLE, 72 micrograms/ml; EM, EN, 0 microgram/ml; Schamberg's disease, 5 micrograms/ml) were not statistically different from that of normal controls [12].
  • These data, together with the wide spectrum of mutant alleles reported in mi mice (which have pigmentary disorders), suggest that MITF could be regarded as a candidate gene in various pigmentation disorders in man [13].


  1. Minocycline-induced immune thrombocytopenia presenting as Schamberg's disease. D'Addario, S.F., Bryan, M.E., Stringer, W.A., Johnson, S.M. Journal of drugs in dermatology : JDD. (2003) [Pubmed]
  2. Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product. Bertolotto, C., Bille, K., Ortonne, J.P., Ballotti, R. J. Cell Biol. (1996) [Pubmed]
  3. SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit. Botchkareva, N.V., Khlgatian, M., Longley, B.J., Botchkarev, V.A., Gilchrest, B.A. FASEB J. (2001) [Pubmed]
  4. Free radical reduction in the human epidermis. Schallreuter, K.U., Wood, J.M. Free Radic. Biol. Med. (1989) [Pubmed]
  5. Oral pentoxifylline vs topical betamethasone in Schamberg disease: a comparative randomized investigator-blinded parallel-group trial. Panda, S., Malakar, S., Lahiri, K. Archives of dermatology. (2004) [Pubmed]
  6. Should pentoxifylline be regarded as an effective treatment for Schamberg's disease? Basak, P.Y., Ergin, S. J. Am. Acad. Dermatol. (2001) [Pubmed]
  7. Pentoxifylline for Schamberg's disease. Burkhart, C.G., Burkhart, K.M. J. Am. Acad. Dermatol. (1998) [Pubmed]
  8. Efficacy of topical treatment of pigmentation skin disorders with plant hydroquinone glucosides as assessed by quantitative color analysis. Clarys, P., Barel, A. J. Dermatol. (1998) [Pubmed]
  9. Photoprotection and skin coloring by oral carotenoids. Raab, W.P., Tronnier, H., Wiskemann, A. Dermatologica (1985) [Pubmed]
  10. Successful treatment of Schamberg's disease with pentoxifylline. Kano, Y., Hirayama, K., Orihara, M., Shiohara, T. J. Am. Acad. Dermatol. (1997) [Pubmed]
  11. Close association between sequence polymorphism in the KIT gene and the roan coat color in horses. Marklund, S., Moller, M., Sandberg, K., Andersson, L. Mamm. Genome (1999) [Pubmed]
  12. Value of the assay for IgA-containing circulating immune complexes in Henoch-Schönlein purpura. Kawana, S., Ohta, M., Nishiyama, S. Dermatologica (1986) [Pubmed]
  13. Mutation of the MITF gene in albinism-deafness syndrome (Tietz syndrome). Amiel, J., Watkin, P.M., Tassabehji, M., Read, A.P., Winter, R.M. Clin. Dysmorphol. (1998) [Pubmed]
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