Disease relevance of Pigmentation Disorders

• Minocycline-induced immune thrombocytopenia presenting as Schamberg's disease [1].

High impact information on Pigmentation Disorders

• Additionally, we showed that microphthalmia, a b-HLH transcription factor associated with pigmentation disorders in mouse, binds to these regulatory elements and modulates the transcriptional activity of the tyrosinase promoter [2].
• Therefore, the blockade of c-kit signaling offers a fully reversible model for hair depigmentation, which might be used for the studies of hair pigmentation disorders [3].
• Recently, both biochemical and clinical studies on the healthy human population, and on patients with pigmentation disorders, suggested a connection between free radical defense by plasma membrane associated thioredoxin reductase and melanin biosynthesis [4].
• Oral pentoxifylline vs topical betamethasone in Schamberg disease: a comparative randomized investigator-blinded parallel-group trial [5].
• Should pentoxifylline be regarded as an effective treatment for Schamberg's disease [6]?

Chemical compound and disease context of Pigmentation Disorders

• Pentoxifylline for Schamberg's disease [7].
• We report the first case of DITP with the clinical picture of Schamberg's disease associated with minocycline therapy [1].
• Hydroquinone is a well known reagent used in the treatment of pigmentation disorders [8].
• A new combination of beta-carotene (25 mg) and canthaxanthin (35 mg) was clinically investigated in 74 patients with various photodermatoses and 111 patients with pigmentation disorders [9].

Anatomical context of Pigmentation Disorders

• Our results suggest that pentoxifylline exerts its therapeutic effects on Schamberg's disease at the level of T-cell adherence to endothelial cells and keratinocytes [10].

Gene context of Pigmentation Disorders

• Phenotypic similarities to some pigmentation disorders in human and mouse, combined with comparative mapping data, identified KIT, encoding the mast cell growth factor receptor, as a major candidate gene for the roan locus (Rn) [11].
• In the other diseases, the mean values of IgA-CIC (SLE, 72 micrograms/ml; EM, EN, 0 microgram/ml; Schamberg's disease, 5 micrograms/ml) were not statistically different from that of normal controls [12].
• These data, together with the wide spectrum of mutant alleles reported in mi mice (which have pigmentary disorders), suggest that MITF could be regarded as a candidate gene in various pigmentation disorders in man [13].

References