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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Value of the assay for IgA-containing circulating immune complexes in Henoch-Schönlein purpura.

Using a modified Raji cell radioimmunoassay, IgA- and IgG-containing circulating immune complexes (IgA-CIC, IgG-CIC) were examined in the sera of 10 patients with Henoch-Schönlein purpura (HSP) and compared with those in the sera of patients with systemic lupus erythematosus ( SLE), erythema multiforme (EM), erythema nodosum (EN) and Schamberg's disease. The mean level of IgA-CIC in HSP (233 micrograms/ml) was statistically higher than that in samples from healthy blood donors (14 micrograms/ml; p less than 0.05). In the other diseases, the mean values of IgA-CIC ( SLE, 72 micrograms/ml; EM, EN, 0 microgram/ml; Schamberg's disease, 5 micrograms/ml) were not statistically different from that of normal controls. The IgA-CIC level in HSP rose markedly during the active phase of the cutaneous manifestation (233 micrograms/ml), declining to the normal range during remission (4 micrograms/ml; p less than 0.05). On the contrary, IgG-CIC did not increase during either phase. There was an isolated patient in whom IgA-CIC seemed to correlate with the clinical events of cutaneous and systemic involvement. The timing was such that a change in the level of IgA-CIC generally preceded disease activity. These findings suggest that IgA-CIC may be an etiologic factor in the cutaneous and systemic involvements of HSP, and the laboratory test for IgA-CIC is not only useful as a research tool, but also valuable as a predictive indicator of disease activity.[1]


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