Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Leukemia, B-Cell

Guha, A. et al., Gordon, J. et al., Vanasse, G.J. et al., Zang, C. et al., Kobayashi, R. et al., et al.

Vanasse, Winn, Rodov, Zieske, Li, Tupper, Tang, Raines, Peters, Yeung, Harlan,

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Disease relevance of Leukemia, B-Cell

The t(14;18)(q32;q21), resulting in deregulated expression of B-cell-leukemia/lymphoma-2 (Bcl-2), represents the genetic hallmark in human follicular lymphomas [1].

High impact information on Leukemia, B-Cell

Myosin has been isolated from guinea pig B-lymphocytic leukemia cells (L2C) [2].
In contrast to most follicular NHL, this leukemia B cell population does not have evidence of bcl-2 gene rearrangement [3].
In contrast, the export of free immunoglobulin (Ig) light chains, an almost consistent feature of the B lymphocytic leukemias, remained relatively constant after TPA treatment [4].
We have used cell surface radioiodination, biosynthetic incorporation of [35S]methionine, and flow cytometry to analyze the effects of interferon gamma (IFN-gamma) and/or phorbol esters (PMA) on the turnover and expression of class I antigens of a human leukemia B cell line [5].
Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia [6].

References

Bcl-2 overexpression leads to increases in suppressor of cytokine signaling-3 expression in B cells and de novo follicular lymphoma. Vanasse, G.J., Winn, R.K., Rodov, S., Zieske, A.W., Li, J.T., Tupper, J.C., Tang, J., Raines, E.W., Peters, M.A., Yeung, K.Y., Harlan, J.M. Mol. Cancer Res. (2004) [Pubmed]
Phosphorylation of lymphocyte myosin catalyzed in vitro and in intact cells. Fechheimer, M., Cebra, J.J. J. Cell Biol. (1982) [Pubmed]
Autoantigen inhibits apoptosis of a human B cell leukemia that produces pathogenic rheumatoid factor. Kobayashi, R., Rassenti, L.Z., Meisenholder, G., Carson, D.A., Kipps, T.J. J. Immunol. (1993) [Pubmed]
Phenotypic modulation of chronic lymphocytic leukemia cells by phorbol ester: induction of IgM secretion and changes in the expression of B cell-associated surface antigens. Gordon, J., Mellstedt, H., Aman, P., Biberfeld, P., Klein, G. J. Immunol. (1984) [Pubmed]
Regulatory effect of interferon-gamma and phorbol esters on the surface expression and biosynthesis of MHC class I antigens by human leukemia cells. Guha, A., Dainiak, N., Freedman, M., Goldschneider, I., Cone, R.E. Cell. Immunol. (1993) [Pubmed]
Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. Zang, C., Liu, H., Posch, M.G., Waechter, M., Facklam, M., Fenner, M.H., Ruthardt, M., Possinger, K., Phillip Koeffler, H., Elstner, E. Leuk. Res. (2004) [Pubmed]

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