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MeSH Review

Genes, bcl-2

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Disease relevance of Genes, bcl-2


High impact information on Genes, bcl-2

  • Similarly, EGFR-deficient fibroblasts are resistant to transformation by SOS-F and rasV12, however, tumorigenicity is restored by expression of the anti-apoptotic bcl-2 gene [6].
  • Transfection of the human bcl-2 gene into an interleukin-3 (IL-3)-dependent, multipotent hemopoietic cell line allowed these cells to survive in the absence of IL-3, both in serum-containing and serum-deprived conditions, and this survival was accompanied by multilineage differentiation [7].
  • The bcl-2 gene encodes a novel G protein [8].
  • To understand survival/death control of germinal center B cell, the expression of four apoptosis-inducing genes, Fas, c-myc, Bax, and P53, together with the survival gene bcl-2, has been analyzed herein among purified tonsillar naive, GC, and memory B cells [9].
  • Expression of the mammalian bcl-2 gene (homologous to ced-9) suppresses apoptosis in many systems [10].

Chemical compound and disease context of Genes, bcl-2


Biological context of Genes, bcl-2

  • Our in silico screening strategy indicated that a hypoxia-inducible proapoptotic member of the Bcl-2 gene family called Nix is expressed during erythropoiesis [16].
  • Evaluation of the methylation status of the bcl-2 gene using the isoschizomers Msp I and Hpa II, and a probe corresponding to the first major exon of the gene showed complete demethylation of both copies of the bcl-2 gene in a region corresponding to a 2.4-kb Msp I fragment in all 20 cases of B-CLL [17].
  • Both an effect of melatonin on the general machinery of apoptosis and a possible regulation of the expression of the cell death related genes bcl-2 and p53 are shown not to be involved [18].
  • Inclusion of bcl-2 gene sequences corresponding to the 5' untranslated region in bcl-2/CAT constructs, however, resulted in p53-dependent down-regulation [19].
  • Recently, we have shown that the p53 tumor suppressor gene product can inhibit expression of the bcl-2 gene [19].

Anatomical context of Genes, bcl-2


Associations of Genes, bcl-2 with chemical compounds


Gene context of Genes, bcl-2

  • BACKGROUND: The bcl-2 gene (also known as BCL2) encodes for a mitochondrial protein thought to prevent apoptosis of normal cells [30].
  • Of the three target nuclear protooncogenes of the IL-2 signaling, c-fos and c-myc genes, but not the bcl-2 gene, were found to be impaired [31].
  • These results provide a further molecular basis for the critical role of Jak3 in IL-2 signaling and also suggest a Jak PTK-independent signaling pathway(s) for the bcl-2 gene induction by IL-2R [31].
  • We conclude that the p50 homodimer is capable of transcriptional activation of the bcl-2 gene and suggest that its nuclear activity contributes to the expression of bcl-2 in LY-ar cells [32].
  • Taken together, these data demonstrate that loss of PTEN leads to up-regulation of the bcl-2 gene, thus contributing to survival and chemoresistance of PCa cells [33].

Analytical, diagnostic and therapeutic context of Genes, bcl-2


  1. Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides. Miayake, H., Tolcher, A., Gleave, M.E. J. Natl. Cancer Inst. (2000) [Pubmed]
  2. Chromosomal abnormalities in patients with Hodgkin's disease: evidence for frequent involvement of the 14q chromosomal region but infrequent bcl-2 gene rearrangement in Reed-Sternberg cells. Poppema, S., Kaleta, J., Hepperle, B. J. Natl. Cancer Inst. (1992) [Pubmed]
  3. Isolated follicular lymphoma cells are resistant to apoptosis and can be grown in vitro in the CD40/stromal cell system. Johnson, P.W., Watt, S.M., Betts, D.R., Davies, D., Jordan, S., Norton, A.J., Lister, T.A. Blood (1993) [Pubmed]
  4. The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells. Zauli, G., Gibellini, D., Caputo, A., Bassini, A., Negrini, M., Monne, M., Mazzoni, M., Capitani, S. Blood (1995) [Pubmed]
  5. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Teixeira, C., Reed, J.C., Pratt, M.A. Cancer Res. (1995) [Pubmed]
  6. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Sibilia, M., Fleischmann, A., Behrens, A., Stingl, L., Carroll, J., Watt, F.M., Schlessinger, J., Wagner, E.F. Cell (2000) [Pubmed]
  7. Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Fairbairn, L.J., Cowling, G.J., Reipert, B.M., Dexter, T.M. Cell (1993) [Pubmed]
  8. The bcl-2 gene encodes a novel G protein. Haldar, S., Beatty, C., Tsujimoto, Y., Croce, C.M. Nature (1989) [Pubmed]
  9. Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. Martinez-Valdez, H., Guret, C., de Bouteiller, O., Fugier, I., Banchereau, J., Liu, Y.J. J. Exp. Med. (1996) [Pubmed]
  10. Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. Stewart, B.W. J. Natl. Cancer Inst. (1994) [Pubmed]
  11. Liposome-mediated transfer of the bcl-2 gene results in neuroprotection after in vivo transient focal cerebral ischemia in an animal model. Cao, Y.J., Shibata, T., Rainov, N.G. Gene Ther. (2002) [Pubmed]
  12. Adenoviral-induced islet cell cytotoxicity is not counteracted by Bcl-2 overexpression. Barbu, A.R., Akusjärvi, G., Welsh, N. Mol. Med. (2002) [Pubmed]
  13. The role of various Bcl-2 domains in the anti-proliferative effect and modulation of cellular glutathione levels: a prominent role for the BH4 domain. Hoetelmans, R.W., Vahrmeijer, A.L., van Vlierberghe, R.L., Keijzer, R., van de Velde, C.J., Mulder, G.J., Van Dierendonck, J.H. Cell Prolif. (2003) [Pubmed]
  14. Apoptosis of human gastric cancer SGC-7901 cells induced by mitomycin combined with sulindac. Ma, L., Xie, Y.L., Yu, Y., Zhang, Q.N. World J. Gastroenterol. (2005) [Pubmed]
  15. Apoptosis-related gene bcl-2 in lung tissue after experimental traumatic brain injury in rats. Yildirim, E., Ozisik, K., Ozisik, P., Emir, M., Yildirim, E., Misirlioglu, M., Tuncer, S., Kilinc, K. Heart, lung & circulation (2006) [Pubmed]
  16. The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. Aerbajinai, W., Giattina, M., Lee, Y.T., Raffeld, M., Miller, J.L. Blood (2003) [Pubmed]
  17. bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Hanada, M., Delia, D., Aiello, A., Stadtmauer, E., Reed, J.C. Blood (1993) [Pubmed]
  18. Melatonin regulates glucocorticoid receptor: an answer to its antiapoptotic action in thymus. Sainz, R.M., Mayo, J.C., Reiter, R.J., Antolin, I., Esteban, M.M., Rodriguez, C. FASEB J. (1999) [Pubmed]
  19. Identification of a p53-dependent negative response element in the bcl-2 gene. Miyashita, T., Harigai, M., Hanada, M., Reed, J.C. Cancer Res. (1994) [Pubmed]
  20. The bcl-2 gene product prevents programmed cell death of ventricular myocytes. Kirshenbaum, L.A., de Moissac, D. Circulation (1997) [Pubmed]
  21. The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2. Decary, S., Decesse, J.T., Ogryzko, V., Reed, J.C., Naguibneva, I., Harel-Bellan, A., Cremisi, C.E. Mol. Cell. Biol. (2002) [Pubmed]
  22. Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells. Buitenhuis, M., Baltus, B., Lammers, J.W., Coffer, P.J., Koenderman, L. Blood (2003) [Pubmed]
  23. Annexin-mediated Ca2+ influx regulates growth plate chondrocyte maturation and apoptosis. Wang, W., Xu, J., Kirsch, T. J. Biol. Chem. (2003) [Pubmed]
  24. Prognostic factors in Hodgkin's disease: multivariate analysis of 327 patients from a single institution. Smolewski, P., Robak, T., Krykowski, E., Blasiñska-Morawiec, M., Niewiadomska, H., Pluzanska, A., Chmielowska, E., Zambrano, O. Clin. Cancer Res. (2000) [Pubmed]
  25. Cyclic bcl-2 gene expression in human uterine endometrium during menstrual cycle. Otsuki, Y., Misaki, O., Sugimoto, O., Ito, Y., Tsujimoto, Y., Akao, Y. Lancet (1994) [Pubmed]
  26. Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA. Talley, A.K., Dewhurst, S., Perry, S.W., Dollard, S.C., Gummuluru, S., Fine, S.M., New, D., Epstein, L.G., Gendelman, H.E., Gelbard, H.A. Mol. Cell. Biol. (1995) [Pubmed]
  27. Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide. Chen, M., Quintans, J., Fuks, Z., Thompson, C., Kufe, D.W., Weichselbaum, R.R. Cancer Res. (1995) [Pubmed]
  28. Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity. Gaffen, S.L., Lai, S.Y., Ha, M., Liu, X., Hennighausen, L., Greene, W.C., Goldsmith, M.A. J. Biol. Chem. (1996) [Pubmed]
  29. High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Federici, M., Hribal, M., Perego, L., Ranalli, M., Caradonna, Z., Perego, C., Usellini, L., Nano, R., Bonini, P., Bertuzzi, F., Marlier, L.N., Davalli, A.M., Carandente, O., Pontiroli, A.E., Melino, G., Marchetti, P., Lauro, R., Sesti, G., Folli, F. Diabetes (2001) [Pubmed]
  30. The Bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. Silvestrini, R., Veneroni, S., Daidone, M.G., Benini, E., Boracchi, P., Mezzetti, M., Di Fronzo, G., Rilke, F., Veronesi, U. J. Natl. Cancer Inst. (1994) [Pubmed]
  31. Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction. Kawahara, A., Minami, Y., Miyazaki, T., Ihle, J.N., Taniguchi, T. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  32. NF-kappaB1 (p50) homodimers contribute to transcription of the bcl-2 oncogene. Kurland, J.F., Kodym, R., Story, M.D., Spurgers, K.B., McDonnell, T.J., Meyn, R.E. J. Biol. Chem. (2001) [Pubmed]
  33. PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression. Huang, H., Cheville, J.C., Pan, Y., Roche, P.C., Schmidt, L.J., Tindall, D.J. J. Biol. Chem. (2001) [Pubmed]
  34. Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma. Gascoyne, R.D., Adomat, S.A., Krajewski, S., Krajewska, M., Horsman, D.E., Tolcher, A.W., O'Reilly, S.E., Hoskins, P., Coldman, A.J., Reed, J.C., Connors, J.M. Blood (1997) [Pubmed]
  35. Mechanisms of action of antimalarials in inflammation: induction of apoptosis in human endothelial cells. Potvin, F., Petitclerc, E., Marceau, F., Poubelle, P.E. J. Immunol. (1997) [Pubmed]
  36. Detection of p53 and bcl-2 protein in carcinoma of the renal pelvis and ureter including dysplasia. Furihata, M., Sonobe, H., Ohtsuki, Y., Yamashita, M., Morioka, M., Yamamoto, A., Terao, N., Kuwahara, M., Fujisaki, N. J. Pathol. (1996) [Pubmed]
  37. bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells. Kondo, S., Yin, D., Aoki, T., Takahashi, J.A., Morimura, T., Takeuchi, J. Exp. Cell Res. (1994) [Pubmed]
  38. bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells. Kyprianou, N., King, E.D., Bradbury, D., Rhee, J.G. Int. J. Cancer (1997) [Pubmed]
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