MeSH Review:
Genes, bcl-2
Barbu,
Akusjärvi,
Welsh,
Kirshenbaum,
de Moissac,
Hoetelmans,
Vahrmeijer,
van Vlierberghe,
Keijzer,
van de Velde,
Mulder,
Van Dierendonck,
Sibilia,
Fleischmann,
Behrens,
Stingl,
Carroll,
Watt,
Schlessinger,
Wagner,
Yildirim,
Ozisik,
Ozisik,
Emir,
Yildirim,
Misirlioglu,
Tuncer,
Kilinc,
Federici,
Hribal,
Perego,
Ranalli,
Caradonna,
Perego,
Usellini,
Nano,
Bonini,
Bertuzzi,
Marlier,
Davalli,
Carandente,
Pontiroli,
Melino,
Marchetti,
Lauro,
Sesti,
Folli,
- Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides. Miayake, H., Tolcher, A., Gleave, M.E. J. Natl. Cancer Inst. (2000)
- Chromosomal abnormalities in patients with Hodgkin's disease: evidence for frequent involvement of the 14q chromosomal region but infrequent bcl-2 gene rearrangement in Reed-Sternberg cells. Poppema, S., Kaleta, J., Hepperle, B. J. Natl. Cancer Inst. (1992)
- Isolated follicular lymphoma cells are resistant to apoptosis and can be grown in vitro in the CD40/stromal cell system. Johnson, P.W., Watt, S.M., Betts, D.R., Davies, D., Jordan, S., Norton, A.J., Lister, T.A. Blood (1993)
- The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells. Zauli, G., Gibellini, D., Caputo, A., Bassini, A., Negrini, M., Monne, M., Mazzoni, M., Capitani, S. Blood (1995)
- Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Teixeira, C., Reed, J.C., Pratt, M.A. Cancer Res. (1995)
- The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Sibilia, M., Fleischmann, A., Behrens, A., Stingl, L., Carroll, J., Watt, F.M., Schlessinger, J., Wagner, E.F. Cell (2000)
- Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Fairbairn, L.J., Cowling, G.J., Reipert, B.M., Dexter, T.M. Cell (1993)
- The bcl-2 gene encodes a novel G protein. Haldar, S., Beatty, C., Tsujimoto, Y., Croce, C.M. Nature (1989)
- Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. Martinez-Valdez, H., Guret, C., de Bouteiller, O., Fugier, I., Banchereau, J., Liu, Y.J. J. Exp. Med. (1996)
- Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. Stewart, B.W. J. Natl. Cancer Inst. (1994)
- Liposome-mediated transfer of the bcl-2 gene results in neuroprotection after in vivo transient focal cerebral ischemia in an animal model. Cao, Y.J., Shibata, T., Rainov, N.G. Gene Ther. (2002)
- Adenoviral-induced islet cell cytotoxicity is not counteracted by Bcl-2 overexpression. Barbu, A.R., Akusjärvi, G., Welsh, N. Mol. Med. (2002)
- The role of various Bcl-2 domains in the anti-proliferative effect and modulation of cellular glutathione levels: a prominent role for the BH4 domain. Hoetelmans, R.W., Vahrmeijer, A.L., van Vlierberghe, R.L., Keijzer, R., van de Velde, C.J., Mulder, G.J., Van Dierendonck, J.H. Cell Prolif. (2003)
- Apoptosis of human gastric cancer SGC-7901 cells induced by mitomycin combined with sulindac. Ma, L., Xie, Y.L., Yu, Y., Zhang, Q.N. World J. Gastroenterol. (2005)
- Apoptosis-related gene bcl-2 in lung tissue after experimental traumatic brain injury in rats. Yildirim, E., Ozisik, K., Ozisik, P., Emir, M., Yildirim, E., Misirlioglu, M., Tuncer, S., Kilinc, K. Heart, lung & circulation (2006)
- The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. Aerbajinai, W., Giattina, M., Lee, Y.T., Raffeld, M., Miller, J.L. Blood (2003)
- bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Hanada, M., Delia, D., Aiello, A., Stadtmauer, E., Reed, J.C. Blood (1993)
- Melatonin regulates glucocorticoid receptor: an answer to its antiapoptotic action in thymus. Sainz, R.M., Mayo, J.C., Reiter, R.J., Antolin, I., Esteban, M.M., Rodriguez, C. FASEB J. (1999)
- Identification of a p53-dependent negative response element in the bcl-2 gene. Miyashita, T., Harigai, M., Hanada, M., Reed, J.C. Cancer Res. (1994)
- The bcl-2 gene product prevents programmed cell death of ventricular myocytes. Kirshenbaum, L.A., de Moissac, D. Circulation (1997)
- The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2. Decary, S., Decesse, J.T., Ogryzko, V., Reed, J.C., Naguibneva, I., Harel-Bellan, A., Cremisi, C.E. Mol. Cell. Biol. (2002)
- Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells. Buitenhuis, M., Baltus, B., Lammers, J.W., Coffer, P.J., Koenderman, L. Blood (2003)
- Annexin-mediated Ca2+ influx regulates growth plate chondrocyte maturation and apoptosis. Wang, W., Xu, J., Kirsch, T. J. Biol. Chem. (2003)
- Prognostic factors in Hodgkin's disease: multivariate analysis of 327 patients from a single institution. Smolewski, P., Robak, T., Krykowski, E., Blasiñska-Morawiec, M., Niewiadomska, H., Pluzanska, A., Chmielowska, E., Zambrano, O. Clin. Cancer Res. (2000)
- Cyclic bcl-2 gene expression in human uterine endometrium during menstrual cycle. Otsuki, Y., Misaki, O., Sugimoto, O., Ito, Y., Tsujimoto, Y., Akao, Y. Lancet (1994)
- Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA. Talley, A.K., Dewhurst, S., Perry, S.W., Dollard, S.C., Gummuluru, S., Fine, S.M., New, D., Epstein, L.G., Gendelman, H.E., Gelbard, H.A. Mol. Cell. Biol. (1995)
- Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide. Chen, M., Quintans, J., Fuks, Z., Thompson, C., Kufe, D.W., Weichselbaum, R.R. Cancer Res. (1995)
- Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity. Gaffen, S.L., Lai, S.Y., Ha, M., Liu, X., Hennighausen, L., Greene, W.C., Goldsmith, M.A. J. Biol. Chem. (1996)
- High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Federici, M., Hribal, M., Perego, L., Ranalli, M., Caradonna, Z., Perego, C., Usellini, L., Nano, R., Bonini, P., Bertuzzi, F., Marlier, L.N., Davalli, A.M., Carandente, O., Pontiroli, A.E., Melino, G., Marchetti, P., Lauro, R., Sesti, G., Folli, F. Diabetes (2001)
- The Bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. Silvestrini, R., Veneroni, S., Daidone, M.G., Benini, E., Boracchi, P., Mezzetti, M., Di Fronzo, G., Rilke, F., Veronesi, U. J. Natl. Cancer Inst. (1994)
- Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction. Kawahara, A., Minami, Y., Miyazaki, T., Ihle, J.N., Taniguchi, T. Proc. Natl. Acad. Sci. U.S.A. (1995)
- NF-kappaB1 (p50) homodimers contribute to transcription of the bcl-2 oncogene. Kurland, J.F., Kodym, R., Story, M.D., Spurgers, K.B., McDonnell, T.J., Meyn, R.E. J. Biol. Chem. (2001)
- PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression. Huang, H., Cheville, J.C., Pan, Y., Roche, P.C., Schmidt, L.J., Tindall, D.J. J. Biol. Chem. (2001)
- Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma. Gascoyne, R.D., Adomat, S.A., Krajewski, S., Krajewska, M., Horsman, D.E., Tolcher, A.W., O'Reilly, S.E., Hoskins, P., Coldman, A.J., Reed, J.C., Connors, J.M. Blood (1997)
- Mechanisms of action of antimalarials in inflammation: induction of apoptosis in human endothelial cells. Potvin, F., Petitclerc, E., Marceau, F., Poubelle, P.E. J. Immunol. (1997)
- Detection of p53 and bcl-2 protein in carcinoma of the renal pelvis and ureter including dysplasia. Furihata, M., Sonobe, H., Ohtsuki, Y., Yamashita, M., Morioka, M., Yamamoto, A., Terao, N., Kuwahara, M., Fujisaki, N. J. Pathol. (1996)
- bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells. Kondo, S., Yin, D., Aoki, T., Takahashi, J.A., Morimura, T., Takeuchi, J. Exp. Cell Res. (1994)
- bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells. Kyprianou, N., King, E.D., Bradbury, D., Rhee, J.G. Int. J. Cancer (1997)