High impact information on Picornaviridae Infections

• These findings suggest that PAI-2 and/or related serpins may form the basis of novel antiviral strategies against picornavirus infections and also therapeutic interventions against ICAM-1-mediated respiratory inflammation [1].
• SCH 38057 (1-[6-(2-chloro-4-methoxyphenoxy)-hexyl]imidazole hydrochloride) is a new, water-soluble antiviral compound that has inhibitory activities against a number of picornavirus infections [2].
• AGM1+ spleen cells contain gamma interferon (IFN-gamma) gene transcripts in the early, sex-dependent production of IFN-gamma after picornavirus infection [3].
• Relationship of p220 cleavage during picornavirus infection to 2A proteinase sequencing [4].
• Induction of chemokines in human astrocytes by picornavirus infection requires activation of both AP-1 and NF-kappa B [5].

Chemical compound and disease context of Picornaviridae Infections

• On the basis of the results of these studies, compound 14 is a strong candidate for clinical evaluation as a systemic agent for the treatment of picornavirus infections [6].
• These hsp can stimulate potent T lymphocyte responses that may then contribute to cardiac damage associated with adriamycin therapy and picornavirus infections [7].

Biological context of Picornaviridae Infections

• One member of the group, eIF-4 gamma, is the target for proteolytic cleavage during picornavirus infection, an event that is thought to be responsible for the inhibition of host cellular mRNA translation [8].

Gene context of Picornaviridae Infections

• Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms [9].
• Multiple sclerosis attacks are associated with picornavirus infections [10].

References