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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Identification of site-specific recombination genes int and xis of the Rhizobium temperate phage 16-3.

Phage 16-3 is a temperate phage of Rhizobium meliloti 41 which integrates its genome with high efficiency into the host chromosome by site-specific recombination through DNA sequences of attB and attP. Here we report the identification of two phage-encoded genes required for recombinations at these sites: int (phage integration) and xis (prophage excision). We concluded that Int protein of phage 16-3 belongs to the integrase family of tyrosine recombinases. Despite similarities to the cognate systems of the lambdoid phages, the 16-3 int xis att system is not active in Escherichia coli, probably due to requirements for host factors that differ in Rhizobium meliloti and E. coli. The application of the 16-3 site-specific recombination system in biotechnology is discussed.[1]

References

  1. Identification of site-specific recombination genes int and xis of the Rhizobium temperate phage 16-3. Semsey, S., Papp, I., Buzas, Z., Patthy, A., Orosz, L., Papp, P.P. J. Bacteriol. (1999) [Pubmed]
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