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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Scopoletin: an inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei.

Bioassay-guided fractionation of an H2O extract of Artemisia feddei has furnished an inducible nitric oxide synthase (iNOS) inhibitory coumarin, scopoletin (1) and one of the inactive sesquiterpenes, achillin (2). Compound 1 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was due to suppression of iNOS mRNA and iNOS protein, as determined by Northern and Western blotting, respectively.[1]

References

  1. Scopoletin: an inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei. Kang, T.H., Pae, H.O., Jeong, S.J., Yoo, J.C., Choi, B.M., Jun, C.D., Chung, H.T., Miyamoto, T., Higuchi, R., Kim, Y.C. Planta Med. (1999) [Pubmed]
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