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Disease relevance of Artemisia


High impact information on Artemisia

  • Wormwood (Artemisia absinthium) was the most significant constituent because it contributed thujone [6].
  • We show that profilins are prominent allergens that can be isolated from tree pollens (Betula verrucosa, birch), from pollens of grasses (Phleum pratense, timothy grass), and weeds (Artemisia vulgaris, mugwort) [7].
  • We defined atopy as a positive result in an assay that tests for specific IgE against the eight most common inhalant allergens in one pool (grass, birch, mugwort, dog, cat, horse, Cladosporum herbarum, house dust mite) [8].
  • Two novel types of O-glycans on the mugwort pollen allergen Art v 1 and their role in antibody binding [9].
  • Art v 1, the major allergen of mugwort (Artemisia vulgaris) pollen contains galactose and arabinose [9].

Chemical compound and disease context of Artemisia


Biological context of Artemisia


Anatomical context of Artemisia


Associations of Artemisia with chemical compounds

  • Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis [24].
  • The glycoprotein allergen Art v II, from the pollen of mugwort (Artemisia vulgaris L.) was treated with peptide:N-glycosidase F (PNGase F) to release asparagine-linked oligosaccharides [25].
  • METHODS: Monoclonal antibodies specific for the major mugwort pollen allergen, Art v 1, representing a 60 kd glycoprotein, were used to detect cross-reactive allergens in other pollens and plant-derived food [26].
  • Artemisia annua plants produce a broad range of volatile compounds, including monoterpenes, which contribute to the characteristic fragrance of this medicinal species [27].
  • These findings suggest a type I IgE-mediated immunologic mechanism as being responsible for the patient's anaphylactic symptoms and also suggest that the patient cross-reacted the pollens of Matricaria chamomilla contained in the chamomile tea because he was previously sensitized to Artemisia pollen [28].

Gene context of Artemisia


Analytical, diagnostic and therapeutic context of Artemisia


  1. The T cell response to Art v 1, the major mugwort pollen allergen, is dominated by one epitope. Jahn-Schmid, B., Kelemen, P., Himly, M., Bohle, B., Fischer, G., Ferreira, F., Ebner, C. J. Immunol. (2002) [Pubmed]
  2. Hypersensitivity to mugwort (Artemisia vulgaris) in patients with peach allergy is due to a common lipid transfer protein allergen and is often without clinical expression. Pastorello, E.A., Pravettoni, V., Farioli, L., Rivolta, F., Conti, A., Ispano, M., Fortunato, D., Bengtsson, A., Bianchi, M. J. Allergy Clin. Immunol. (2002) [Pubmed]
  3. Remission of allergic rhinitis: An 8-year observational study. Bodtger, U., Linneberg, A. J. Allergy Clin. Immunol. (2004) [Pubmed]
  4. Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transcription factor kappa B activation in mouse skin. Seo, H.J., Park, K.K., Han, S.S., Chung, W.Y., Son, M.W., Kim, W.B., Surh, Y.J. Int. J. Cancer (2002) [Pubmed]
  5. Selective inhibition of 5-lipoxygenase by natural compounds isolated from Chinese plants, Artemisia rubripes Nakai. Koshihara, Y., Neichi, T., Murota, S., Lao, A., Fujimoto, Y., Tatsuno, T. FEBS Lett. (1983) [Pubmed]
  6. Vincent van Gogh and the thujone connection. Arnold, W.N. JAMA (1988) [Pubmed]
  7. Profilins constitute a novel family of functional plant pan-allergens. Valenta, R., Duchene, M., Ebner, C., Valent, P., Sillaber, C., Deviller, P., Ferreira, F., Tejkl, M., Edelmann, H., Kraft, D. J. Exp. Med. (1992) [Pubmed]
  8. Frequency of atopy in the Arctic in 1987 and 1998. Krause, T., Koch, A., Friborg, J., Poulsen, L.K., Kristensen, B., Melbye, M. Lancet (2002) [Pubmed]
  9. Two novel types of O-glycans on the mugwort pollen allergen Art v 1 and their role in antibody binding. Leonard, R., Petersen, B.O., Himly, M., Kaar, W., Wopfner, N., Kolarich, D., van Ree, R., Ebner, C., Duus, J.Ø., Ferreira, F., Altmann, F. J. Biol. Chem. (2005) [Pubmed]
  10. A bioassay for inhibition of serotonin release from bovine platelets. Marles, R.J., Kaminski, J., Arnason, J.T., Pazos-Sanou, L., Heptinstall, S., Fischer, N.H., Crompton, C.W., Kindack, D.G., Awang, D.V. J. Nat. Prod. (1992) [Pubmed]
  11. Metabolism of eupatilin in rats using liquid chromatography/electrospray mass spectrometry. Ji, H.Y., Lee, H.W., Shim, H.J., Kim, S.H., Kim, W.B., Lee, H.S. Biomed. Chromatogr. (2004) [Pubmed]
  12. Ethanol extract from Artemisia vestita, a traditional Tibetan medicine, exerts anti-sepsis action through down-regulating the MAPK and NF-kappaB pathways. Sun, Y., Li, Y.H., Wu, X.X., Zheng, W., Guo, Z.H., Li, Y., Chen, T., Hua, Z.C., Xu, Q. Int. J. Mol. Med. (2006) [Pubmed]
  13. Efficacy of use of colonoscopy in dextran sulfate sodium induced ulcerative colitis in rats: the evaluation of the effects of antioxidant by colonoscopy. Ahn, B.O., Ko, K.H., Oh, T.Y., Cho, H., Kim, W.B., Lee, K.J., Cho, S.W., Hahm, K.B. International journal of colorectal disease. (2001) [Pubmed]
  14. Protective effect of Artemisia douglasiana Besser extracts in gastric mucosal injury. Repetto, M., María, A., Guzmán, J., Giordano, O., Llesuy, S. J. Pharm. Pharmacol. (2003) [Pubmed]
  15. Inhibitors of the LPS-induced NF-kappaB activation from Artemisia sylvatica. Jin, H.Z., Lee, J.H., Lee, D., Hong, Y.S., Kim, Y.H., Lee, J.J. Phytochemistry (2004) [Pubmed]
  16. Mode of complement activation by acidic heteroglycans from the leaves of Artemisia princeps PAMP. Yamada, H., Nagai, T., Cyong, J.C., Otsuka, Y. Chem. Pharm. Bull. (1991) [Pubmed]
  17. Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16. Lee, H.G., Yu, K.A., Oh, W.K., Baeg, T.W., Oh, H.C., Ahn, J.S., Jang, W.C., Kim, J.W., Lim, J.S., Choe, Y.K., Yoon, D.Y. Journal of ethnopharmacology. (2005) [Pubmed]
  18. AIP1, a water-soluble fraction from Artemisia iwayomogi, suppresses thymocyte apoptosis in vitro and down-regulates the expression of Fas gene. Hwang, J.S., Ji, H.J., Koo, K.A., Lee, N.H., Yeo, H.K., Cheong, S.W., Park, J.H., Oh, G.S., Yoon, C.S., Youn, H.J. Biol. Pharm. Bull. (2005) [Pubmed]
  19. Isolation and biological effects of 7-O-methyleriodictyol, a flavanone isolated from Artemisia monosperma, on rat isolated smooth muscles. Abu-Niaaj, L., Abu-Zarga, M., Sabri, S., Abdalla, S. Planta Med. (1993) [Pubmed]
  20. Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells. Jang, S.I., Kim, Y.J., Kim, H.J., Lee, J.C., Kim, H.Y., Kim, Y.C., Yun, Y.G., Yu, H.H., You, Y.O. Life Sci. (2006) [Pubmed]
  21. Increased susceptibility of ethanol-treated gastric mucosa to naproxen and its inhibition by DA-9601, an Artemisia asiatica extract. Oh, T.Y., Ahn, G.J., Choi, S.M., Ahn, B.O., Kim, W.B. World J. Gastroenterol. (2005) [Pubmed]
  22. Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants. Stalińska, K., Guzdek, A., Rokicki, M., Koj, A. J. Physiol. Pharmacol. (2005) [Pubmed]
  23. Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients. Bublin, M., Radauer, C., Wilson, I.B., Kraft, D., Scheiner, O., Breiteneder, H., Hoffmann-Sommergruber, K. FASEB J. (2003) [Pubmed]
  24. Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis. Hemmerlin, A., Rivera, S.B., Erickson, H.K., Poulter, C.D. J. Biol. Chem. (2003) [Pubmed]
  25. Structural analysis of the glycoprotein allergen Art v II from the pollen of mugwort (Artemisia vulgaris L.). Nilsen, B.M., Sletten, K., Paulsen, B.S., O'Neill, M., van Halbeek, H. J. Biol. Chem. (1991) [Pubmed]
  26. Identification of a 60 kd cross-reactive allergen in pollen and plant-derived food. Heiss, S., Fischer, S., Müller, W.D., Weber, B., Hirschwehr, R., Spitzauer, S., Kraft, D., Valenta, R. J. Allergy Clin. Immunol. (1996) [Pubmed]
  27. Cloning and functional characterization of a beta-pinene synthase from Artemisia annua that shows a circadian pattern of expression. Lu, S., Xu, R., Jia, J.W., Pang, J., Matsuda, S.P., Chen, X.Y. Plant Physiol. (2002) [Pubmed]
  28. Anaphylactic reaction after the ingestion of chamomile tea: a study of cross-reactivity with other composite pollens. Subiza, J., Subiza, J.L., Hinojosa, M., Garcia, R., Jerez, M., Valdivieso, R., Subiza, E. J. Allergy Clin. Immunol. (1989) [Pubmed]
  29. Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma Plus LPS. Jang, S., Kim, Y.J., Lee, W.Y., Kwak, K.C., Baek, S.H., Kwak, G.B., Yun, Y.G., Kwon, T.O., Chung, H.T., Chai, K.Y. Arch. Pharm. Res. (2005) [Pubmed]
  30. A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis. Wang, M., Xing, Z.M., Lu, C., Ma, Y.X., Yu, D.L., Yan, Z., Wang, S.W., Yu, L.S. Hum. Genet. (2003) [Pubmed]
  31. Scopoletin: an inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei. Kang, T.H., Pae, H.O., Jeong, S.J., Yoo, J.C., Choi, B.M., Jun, C.D., Chung, H.T., Miyamoto, T., Higuchi, R., Kim, Y.C. Planta Med. (1999) [Pubmed]
  32. Extraction of artemisinin and artemisinic acid from Artemisia annua L. using supercritical carbon dioxide. Kohler, M., Haerdi, W., Christen, P., Veuthey, J.L. Journal of chromatography. A. (1997) [Pubmed]
  33. Purification of the glycoprotein allergen Ag7 from mugwort pollen by concanavalin A affinity chromatography. Nilsen, B.M., Smestad Paulsen, B., Clonis, Y., Mellbye, K.S. J. Biotechnol. (1990) [Pubmed]
  34. The effects of Artemisia filifolia and Helenium flexuosum on disposition of antipyrine in rabbits. Eissa, F.Z., Burrows, G.E., Clarke, C.R. Veterinary and human toxicology. (1995) [Pubmed]
  35. A double-blind trial of oral immunotherapy for Artemisia pollen asthma with evaluation of bronchial response to the pollen allergen and serum-specific IgE antibody. Leng, X., Fu, Y.X., Ye, S.T., Duan, S.Q. Annals of allergy. (1990) [Pubmed]
  36. In vivo tests with pollen extracts previously investigated by means of direct RAST titration allergen assay. Stenius-Aarniala, B.S., Malmberg, C.H., Holopainen, E.E., Björksten, F. Clin. Allergy (1978) [Pubmed]
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