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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Velvet antler polypeptides promoted proliferation of chondrocytes and osteoblast precursors and fracture healing.

AIM: To study the effects of velvet antler (VA) total polypeptides (VATP) and VA polypeptides, VAP-A, VAP-B, and VAP-C on proliferation of chondrocytes and osteoblast precusors. METHODS: Chondrocytes (rabbit and human fetus) and osteoblast precusors (chick embryo) were incubated in the culture medium containing VATP or VAP-A, VAP-B, and VAP-C. [3H]TdR incorporation into DNA was measured. Fracture healing-promoting action of VATP was determined in rats. RESULTS: VATP 50-200 mg.L-1 and VAP-B 12.5, 25, and 50 mg.L-1 showed most marked proliferation-promoting activity for rabbit costed chondrocytes and increased incorporation of [3H]TdR from (73 +/- 9) Bq (control group) to (272 +/- 55), (327 +/- 38), and (415 +/- 32) Bq, respectively (P < 0.01). The activity of VAP-A was weaker than that of VAP-B, and VAP-C had no activity. VATP 10 and 20 mg.kg-1 by local injection into the cross-section fracture area accelerated healing of radial fracture. The healing rate of VATP-treated group was higher (75%) than that of control group (25%) (P < 0.05). CONCLUTION: VATP accelerated fracture healing by stimulating proliferation of chondrocytes and osteoblast precursors.[1]

References

  1. Velvet antler polypeptides promoted proliferation of chondrocytes and osteoblast precursors and fracture healing. Zhou, Q.L., Guo, Y.J., Wang, L.J., Wang, Y., Liu, Y.Q., Wang, Y., Wang, B.X. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1999) [Pubmed]
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