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Gene Review

VAPB  -  VAMP (vesicle-associated membrane protein)...

Homo sapiens

Synonyms: ALS8, UNQ484/PRO983, VAMP-B, VAMP-B/VAMP-C, VAMP-associated protein B/C, ...
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Disease relevance of VAPB


High impact information on VAPB


Biological context of VAPB

  • Two frequent tetra-nucleotide repeat polymorphisms between VAPB and STX16 on chromosome 20q13 [6].
  • Genetic analysis for all exons of the VAPB gene by DHPLC revealed 5 variant profiles in 83 out of 125 SALS patients [7].
  • In the HCV replicon cells, the knockdown of endogenous VAP-B by small interfering RNA decreased expression of NS5B, but not of NS5A [3].
  • These results suggest that VAP-B, in addition to VAP-A, plays an important role in the replication of the HCV genome [3].

Anatomical context of VAPB


Associations of VAPB with chemical compounds

  • NS5A interacts with the coiled-coil domain of VAP-B via 70 residues in the N-terminal and 341 to 344 amino acids in the C-terminal polyproline cluster region [3].

Other interactions of VAPB


Analytical, diagnostic and therapeutic context of VAPB


  1. A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. Nishimura, A.L., Mitne-Neto, M., Silva, H.C., Richieri-Costa, A., Middleton, S., Cascio, D., Kok, F., Oliveira, J.R., Gillingwater, T., Webb, J., Skehel, P., Zatz, M. Am. J. Hum. Genet. (2004) [Pubmed]
  2. Expanding the phenotypes of the Pro56Ser VAPB mutation: Proximal SMA with dysautonomia. Marques, V.D., Barreira, A.A., Davis, M.B., Abou-Sleiman, P.M., Silva, W.A., Zago, M.A., Sobreira, C., Fazan, V., Marques, W. Muscle Nerve (2006) [Pubmed]
  3. Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B. Hamamoto, I., Nishimura, Y., Okamoto, T., Aizaki, H., Liu, M., Mori, Y., Abe, T., Suzuki, T., Lai, M.M., Miyamura, T., Moriishi, K., Matsuura, Y. J. Virol. (2005) [Pubmed]
  4. Characterization of Amyotrophic Lateral Sclerosis-linked P56S Mutation of Vesicle-associated Membrane Protein-associated Protein B (VAPB/ALS8). Kanekura, K., Nishimoto, I., Aiso, S., Matsuoka, M. J. Biol. Chem. (2006) [Pubmed]
  5. Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction. Amarilio, R., Ramachandran, S., Sabanay, H., Lev, S. J. Biol. Chem. (2005) [Pubmed]
  6. Two frequent tetra-nucleotide repeat polymorphisms between VAPB and STX16 on chromosome 20q13. Bastepe, M., Pincus, J.E., Jüppner, H. Mol. Cell. Probes (1999) [Pubmed]
  7. Sporadic ALS is not associated with VAPB gene mutations in Southern Italy. Conforti, F.L., Sprovieri, T., Mazzei, R., Ungaro, C., Tessitore, A., Tedeschi, G., Patitucci, A., Magariello, A., Gabriele, A., Labella, V., Simone, I.L., Majorana, G., Monsurrò, M.R., Valentino, P., Muglia, M., Quattrone, A. Journal of negative results in biomedicine [electronic resource]. (2006) [Pubmed]
  8. Velvet antler polypeptides promoted proliferation of chondrocytes and osteoblast precursors and fracture healing. Zhou, Q.L., Guo, Y.J., Wang, L.J., Wang, Y., Liu, Y.Q., Wang, Y., Wang, B.X. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1999) [Pubmed]
  9. Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. Nishimura, Y., Hayashi, M., Inada, H., Tanaka, T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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