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VAPA  -  VAMP (vesicle-associated membrane protein)...

Homo sapiens

Synonyms: 33 kDa VAMP-associated protein, VAMP-A, VAMP-associated protein A, VAP-33, VAP-A, ...
 
 
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Disease relevance of VAPA

 

High impact information on VAPA

 

Biological context of VAPA

 

Anatomical context of VAPA

 

Associations of VAPA with chemical compounds

 

Physical interactions of VAPA

 

Regulatory relationships of VAPA

 

Other interactions of VAPA

 

Analytical, diagnostic and therapeutic context of VAPA

  • Thus, both immunofluorescence and fractionation data suggest that VAP-33 is present in two distinct pools in the cells [8].
  • The IVC within the brain was observed in 59% of cases, more frequently in patients treated with polychemotherapy, especially according to TAD or VAPA protocols [18].
  • Immunoprecipitation and mutation analyses revealed that VAP-B binds to both NS5A and NS5B in mammalian cells and forms homo- and heterodimers with VAP-A [10].

References

  1. Chemotherapy for acute myelogenous leukemia in children and adults: VAPA update. Weinstein, H.J., Mayer, R.J., Rosenthal, D.S., Coral, F.S., Camitta, B.M., Gelber, R.D. Blood (1983) [Pubmed]
  2. Intensive sequential chemotherapy for children with acute myelogenous leukemia: VAPA, 80-035, and HI-C-Daze. Grier, H.E., Gelber, R.D., Link, M.P., Camitta, B.P., Clavell, L.A., Weistein, H.J. Leukemia (1992) [Pubmed]
  3. Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft. Gao, L., Aizaki, H., He, J.W., Lai, M.M. J. Virol. (2004) [Pubmed]
  4. Norwalk virus nonstructural protein p48 forms a complex with the SNARE regulator VAP-A and prevents cell surface expression of vesicular stomatitis virus G protein. Ettayebi, K., Hardy, M.E. J. Virol. (2003) [Pubmed]
  5. Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication. Evans, M.J., Rice, C.M., Goff, S.P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Efficient Trafficking of Ceramide from the Endoplasmic Reticulum to the Golgi Apparatus Requires a VAMP-associated Protein-interacting FFAT Motif of CERT. Kawano, M., Kumagai, K., Nishijima, M., Hanada, K. J. Biol. Chem. (2006) [Pubmed]
  7. Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum. Wyles, J.P., McMaster, C.R., Ridgway, N.D. J. Biol. Chem. (2002) [Pubmed]
  8. VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction. Lapierre, L.A., Tuma, P.L., Navarre, J., Goldenring, J.R., Anderson, J.M. J. Cell. Sci. (1999) [Pubmed]
  9. Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP. Weir, M.L., Klip, A., Trimble, W.S. Biochem. J. (1998) [Pubmed]
  10. Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B. Hamamoto, I., Nishimura, Y., Okamoto, T., Aizaki, H., Liu, M., Mori, Y., Abe, T., Suzuki, T., Lai, M.M., Miyamura, T., Moriishi, K., Matsuura, Y. J. Virol. (2005) [Pubmed]
  11. Molecular cloning and partial characterization of a plant VAP33 homologue with a major sperm protein domain. Laurent, F., Labesse, G., de Wit, P. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  12. Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface. Li, Y., Fanning, A.S., Anderson, J.M., Lavie, A. J. Mol. Biol. (2005) [Pubmed]
  13. VAP-A binds promiscuously to both v- and tSNAREs. Weir, M.L., Xie, H., Klip, A., Trimble, W.S. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  14. Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein. Tu, H., Gao, L., Shi, S.T., Taylor, D.R., Yang, T., Mircheff, A.K., Wen, Y., Gorbalenya, A.E., Hwang, S.B., Lai, M.M. Virology (1999) [Pubmed]
  15. (1)H, (13)C and (15)N resonance assignments of the VAP-A: OSBP complex. Furuita, K., Mishima, M., Kojima, C. J. Biomol. NMR (2006) [Pubmed]
  16. Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. Nishimura, Y., Hayashi, M., Inada, H., Tanaka, T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  17. Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants. Lehto, M., Hynynen, R., Karjalainen, K., Kuismanen, E., Hyvärinen, K., Olkkonen, V.M. Exp. Cell Res. (2005) [Pubmed]
  18. Intravascular coagulation in the central nervous system in patients with acute myeloblastic leukemias. Nowacki, P., Zdziarska, B. Neuropatologia polska. (1993) [Pubmed]
 
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