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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A novel calcitonin receptor gene in human osteoclasts from normal bone marrow.

The calcitonin receptor (CTR) gene in human osteoclasts formed in a human bone marrow cell culture system was examined by reverse transcription-polymerase chain reaction (RT-PCR). The RT-PCR results indicated that the 5'-untranslated region (5'UTR) was different between CTR mRNAs in human osteoclasts and in a mammary tumor cell line, MCF-7 cells. We isolated the 5'UTR of the CTR gene from human osteoclasts, whose sequence had only 28.6% identity with that of other CTR genes reported until now. In a radioligand binding assay, COS-1 cells transfected with the osteoclast CTR gene bound to [125I]human CT (hCT). These results provided evidence that the CTR gene cloned from human osteoclasts was expressed functionally and its coding protein was identical to MCF-7 cell CTR.[1]


  1. A novel calcitonin receptor gene in human osteoclasts from normal bone marrow. Nishikawa, T., Ishikawa, H., Yamamoto, S., Koshihara, Y. FEBS Lett. (1999) [Pubmed]
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