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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance.

In Arabidopsis thaliana, the Salt Overly Sensitive 2 (SOS2) gene is required for intracellular Na(+) and K(+) homeostasis. Mutations in SOS2 cause Na(+) and K(+) imbalance and render plants more sensitive toward growth inhibition by high Na(+) and low K(+) environments. We isolated the SOS2 gene through positional cloning. SOS2 is predicted to encode a serine/threonine type protein kinase with an N-terminal catalytic domain similar to that of the yeast SNF1 kinase. Sequence analyses of sos2 mutant alleles reveal that both the N-terminal catalytic domain and the C-terminal regulatory domain of SOS2 are functionally essential. The steady-state level of SOS2 transcript is up-regulated by salt stress in the root. Autophosphorylation assays show that SOS2 is an active protein kinase. In the recessive sos2-5 allele, a conserved glycine residue in the kinase catalytic domain is changed to glutamate. This mutation abolishes SOS2 autophosphorylation, indicating that SOS2 protein kinase activity is required for salt tolerance.[1]


  1. The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance. Liu, J., Ishitani, M., Halfter, U., Kim, C.S., Zhu, J.K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
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