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Ramakrishnan, L. et al.

Ramakrishnan, Federspiel, Falkow,

Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family.

Pathogenic mycobacteria, including the agent of tuberculosis, Mycobacterium tuberculosis, must replicate in macrophages for long-term persistence within their niche during chronic infection: organized collections of macrophages and lymphocytes called granulomas. We identified several genes preferentially expressed when Mycobacterium marinum, the cause of fish and amphibian tuberculosis, resides in host granulomas and/or macrophages. Two were homologs of M. tuberculosis PE/PE-PGRS genes, a family encoding numerous repetitive glycine-rich proteins of unknown function. Mutation of two PE-PGRS genes produced M. marinum strains incapable of replication in macrophages and with decreased persistence in granulomas. Our results establish a direct role in virulence for some PE-PGRS proteins.[1]

References

Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family. Ramakrishnan, L., Federspiel, N.A., Falkow, S. Science (2000) [Pubmed]

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