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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Granular acute lymphoblastic leukemia with hypereosinophilic syndrome.

A four-year-old boy presented with marked peripheral blood eosinophilia (absolute eosinophil count of 54 x 10(9)/1), features of hypereosinophilic syndrome, and acute lymphoblastic leukemia (ALL-L2), the latter characterized by the presence of granular blasts. Blasts were negative for myeloperoxidase, non-specific esterase, acid phosphatase, periodic-acid Schiff stain, and toluidine blue. They exhibited an early pre-B immunophenotype (TdT, CD19, CD10, CD20 and CD22 positive) and stained negative for T (CD7, CD2, CD5 and CD3) and myeloid markers (MPO, CD33 and CD13). Chromosomal analysis revealed a normal karyotype. To the best of our knowledge, this case represents the first report of the coexistence of granular ALL and hypereosinophilic syndrome.[1]

References

  1. Granular acute lymphoblastic leukemia with hypereosinophilic syndrome. Jain, P., Kumar, R., Gujral, S., Kumar, A., Singh, A., Jain, Y., Dubey, S., Anand, M., Arya, L.S. Ann. Hematol. (2000) [Pubmed]
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