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Gene Review

CD5  -  CD5 molecule

Homo sapiens

Synonyms: LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5, T1
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Disease relevance of CD5


Psychiatry related information on CD5

  • In contrast, within the CG, paternal parenting stress was negatively associated with adaptive parenting at T1 but showed no enduring negative effects in longitudinal analyses [5].
  • For both groups, there was a direct positive association between T1 use utility and T2 alcohol consumption and an indirect association with T2 alcohol problems via alcohol consumption [6].

High impact information on CD5

  • The CD5 molecule can function as a negative regulator of BCR signaling that may help prevent inappropriate activation of autoreactive B-1a cells [7].
  • The B-cell surface protein CD72/Lyb-2 is the ligand for CD5 [8].
  • Here we report that CD5 specifically interacts with the cell-surface protein CD72 exclusive to B cells [8].
  • The glycoprotein CD5 is expressed on the surface membrane of all mature T cells and a small proportion of B lymphocytes [8].
  • To identify the ligand for CD5 we purified the human CD5 protein, labelled it with biotin and used it as a probe [8].

Chemical compound and disease context of CD5


Biological context of CD5


Anatomical context of CD5

  • Here we show that CD2 and CD3 independently associate with CD5 in human PBMC and Jurkat cells [15].
  • The difference in activity of anti-CD5 MAb on synovial fluid T cells compared with peripheral blood T cells was not due to different surface expression of CD5 [3].
  • Expression of RAGs in peripheral B cells outside germinal centers is associated with the expression of CD5 [16].
  • Phenotyping of lymphocytes recovered from immunotoxin-treated marrow demonstrated that residual T cells were CD5 negative in all cases tested [4].
  • Moreover, findings reported here suggest that CD7, as well as CD2 and CD5, antigens appear on precursor cells prior to entry into the thymus and support a model for the developmental hierarchy of TCR genes during early T cell ontogeny [17].

Associations of CD5 with chemical compounds

  • CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn [13].
  • Further, anti-CD5 and anti-p56lck coprecipitated each other in a variety of detergents, including Nonidet P-40 and Triton X-100 [1].
  • Cross-linking of CD5 or CD28 induces an early rise of cytoplasmic free calcium concentration ([Ca2+)]i) and both this rise and CD69 expression were inhibited by chelation of extracellular Ca2+ with ethyleneglycol-bis-(2-aminoethyl)-tetraacetate (EGTA) [18].
  • Linomide also induced a transient increase in the NK-cells, the NK 1.1 cells, and the CD5 B-cells (P = 0.02) [19].
  • A CD 5-deficient mutant clone Jurkat 1.15 was generated by treatment with ethyl methanesulfonate followed by selection with anti-CD 5 mAb plus complement [20].
  • Metabolic pathways, namely cholesterol synthesis and adipogenesis, are also enhanced by CD5 [21].

Physical interactions of CD5

  • CD5 is a T-cell-specific antigen which binds to the B-cell antigen CD72 and acts as a coreceptor in the stimulation of T-cell growth [1].
  • CD5 coprecipitates with CD2 in CD3-deficient cells and, conversely, coprecipitates with CD3 in cells devoid of CD2 [15].
  • In this study, we demonstrate that CD5 is coupled to the protein-tyrosine kinase p56lck and can act as a substrate for p56lck [1].

Enzymatic interactions of CD5

  • The Rac1-specific guanine nucleotide exchange factor Vav is heavily phosphorylated on tyrosine residues upon CD5 costimulation, which is a prerequisite for its activation [22].
  • Recently it has been proposed that CD5 function is dependent on the recruitment of the tyrosine phosphatase SHP-1 to tyrosine-phosphorylated CD5 and subsequent dephosphorylation of signaling molecules [23].

Regulatory relationships of CD5

  • In this study, we present evidence that activated mature CD5-positive human tonsil B cells coexpress both RAG1 and RAG2 mRNA and protein, and display DNA cleavage resulting from their recombinase activity [16].
  • Human interleukin 4 down-regulates the surface expression of CD5 on normal and leukemic B cells [24].
  • No CD19+ B cells outside GALT expressed CD5, but a very small portion of the lamina propria B-cell blasts were positive for CD28 [25].
  • We find that CRI-positive cells and CD5 B cells both co-express slgD but fail to bind peanut agglutinin or MAbs specific for CD10, indicating that both cell types reside in the mantle zones of secondary B cell follicles [26].
  • The percentage of LNL expressing CD2 also increased but those expressing CD5 decreased [27].

Other interactions of CD5

  • In addition, the CD38 antigen was brightly expressed on early T lymphocytes in human thymus, characterized by CD34, CD5, and CD7 expression [28].
  • The T cell surface molecules CD5 and CD28 have been shown to be receptors for accessory signals in T cell activation [29].
  • Of the T-cell markers, CD5, CD6, and CD7 showed lineage promiscuity by their presence on some B-NHL [30].
  • Compared with uninfected cells, a significantly lower density was found on infected cells in labelling for CD4, CD5 and anti-HLA-DR [31].
  • Immobilized anti-CD5 together with prolonged activation of protein kinase C induce interleukin 2-dependent T cell growth: evidence for signal transduction through CD5 [32].

Analytical, diagnostic and therapeutic context of CD5


  1. The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck. Raab, M., Yamamoto, M., Rudd, C.E. Mol. Cell. Biol. (1994) [Pubmed]
  2. De novo CD5-positive and Richter's syndrome-associated diffuse large B cell lymphomas are genotypically distinct. Matolcsy, A., Chadburn, A., Knowles, D.M. Am. J. Pathol. (1995) [Pubmed]
  3. Inhibition of synovial fluid T cell proliferation by anti-CD5 monoclonal antibodies. A potential mechanism for their immunotherapeutic action in vivo. Verwilghen, J., Kingsley, G.H., Ceuppens, J.L., Panayi, G.S. Arthritis Rheum. (1992) [Pubmed]
  4. T cell depletion with anti-CD5 immunotoxin in histocompatible bone marrow transplantation. The correlation between residual CD5 negative T cells and subsequent graft-versus-host disease. Filipovich, A.H., Vallera, D., McGlave, P., Polich, D., Gajl-Peczalska, K., Haake, R., Lasky, L., Blazar, B., Ramsay, N.K., Kersey, J. Transplantation (1990) [Pubmed]
  5. Predictors of Parenting Behavior Trajectories Among Families of Young Adolescents with and without Spina Bifida. Greenley, R.N., Holmbeck, G.N., Rose, B.M. Journal of pediatric psychology (2006) [Pubmed]
  6. An affective and cognitive model of marijuana and alcohol problems. Simons, J.S., Carey, K.B. Addictive behaviors. (2006) [Pubmed]
  7. Origins and functions of B-1 cells with notes on the role of CD5. Berland, R., Wortis, H.H. Annu. Rev. Immunol. (2002) [Pubmed]
  8. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. Van de Velde, H., von Hoegen, I., Luo, W., Parnes, J.R., Thielemans, K. Nature (1991) [Pubmed]
  9. Monoclonal antibodies recognizing CD5, CD10 and CD23 in formalin-fixed, paraffin-embedded tissue: production and assessment of their value in the diagnosis of small B-cell lymphoma. Watson, P., Wood, K.M., Lodge, A., McIntosh, G.G., Milton, I., Piggott, N.H., Proctor, S.J., Taylor, P.R., Smith, S., Jack, F., Bell, H., Steward, M., Anderson, J.J., Horne, C.H., Angus, B. Histopathology (2000) [Pubmed]
  10. Fludarabine induces apoptosis in chronic lymphocytic leukemia--the role of P53, Bcl-2, Bax, Mcl-1, and Bag-1 proteins. Faria, J.R., Yamamoto, M., Faria, R.M., Kerbauy, J., Oliveira, J.S. Braz. J. Med. Biol. Res. (2006) [Pubmed]
  11. Single amino-acid changes in HIV envelope affect viral tropism and receptor binding. Cordonnier, A., Montagnier, L., Emerman, M. Nature (1989) [Pubmed]
  12. Cranial neuropathy heralding otherwise occult AIDS-related large cell lymphoma. Berger, J.R., Flaster, M., Schatz, N., Droller, D., Benedetto, P., Poblete, R., Post, M.J. Journal of clinical neuro-ophthalmology. (1993) [Pubmed]
  13. CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn. Burgess, K.E., Yamamoto, M., Prasad, K.V., Rudd, C.E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  14. Identification and characterization of circulating human transitional B cells. Sims, G.P., Ettinger, R., Shirota, Y., Yarboro, C.H., Illei, G.G., Lipsky, P.E. Blood (2005) [Pubmed]
  15. CD2 and CD3 associate independently with CD5 and differentially regulate signaling through CD5 in Jurkat T cells. Carmo, A.M., Castro, M.A., Arosa, F.A. J. Immunol. (1999) [Pubmed]
  16. Expression of RAGs in peripheral B cells outside germinal centers is associated with the expression of CD5. Hillion, S., Saraux, A., Youinou, P., Jamin, C. J. Immunol. (2005) [Pubmed]
  17. Rearrangement of T cell receptor beta, gamma, and delta gene loci in human pre-T cell acute lymphoblastic leukemia. Raghavachar, A., Thiel, E., Hansen-Hagge, T.E., Kranz, B., Bartram, C.R. Leukemia (1989) [Pubmed]
  18. Ligation of the CD5 or CD28 molecules on resting human T cells induces expression of the early activation antigen CD69 by a calcium- and tyrosine kinase-dependent mechanism. Vandenberghe, P., Verwilghen, J., Van Vaeck, F., Ceuppens, J.L. Immunology (1993) [Pubmed]
  19. Inhibition of the progression of multiple sclerosis by linomide is associated with upregulation of CD4+/CD45RA+ cells and downregulation of CD4+/CD45RO+ cells. Lehmann, D., Karussis, D., Mizrachi-Koll, R., Linde, A.S., Abramsky, O. Clin. Immunol. Immunopathol. (1997) [Pubmed]
  20. Expression and function of a CD5 cDNA in human and murine T cells. Nishimura, Y., Bierer, B.E., Jones, W.K., Jones, N.H., Strominger, J.L., Burakoff, S.J. Eur. J. Immunol. (1988) [Pubmed]
  21. Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype. Gary-Gouy, H., Sainz-Perez, A., Marteau, J.B., Marfaing-Koka, A., Delic, J., Merle-Beral, H., Galanaud, P., Dalloul, A. J. Immunol. (2007) [Pubmed]
  22. Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes. Gringhuis, S.I., de Leij, L.F., Coffer, P.J., Vellenga, E. Mol. Cell. Biol. (1998) [Pubmed]
  23. Determination of the tyrosine phosphorylation sites in the T cell transmembrane glycoprotein CD5. Dennehy, K.M., Ferris, W.F., Veenstra, H., Zuckerman, L.A., Killeen, N., Beyers, A.D. Int. Immunol. (2001) [Pubmed]
  24. Human interleukin 4 down-regulates the surface expression of CD5 on normal and leukemic B cells. Defrance, T., Vanbervliet, B., Durand, I., Banchereau, J. Eur. J. Immunol. (1989) [Pubmed]
  25. Immunoglobulin A cell distribution in the human small intestine: phenotypic and functional characteristics. Farstad, I.N., Carlsen, H., Morton, H.C., Brandtzaeg, P. Immunology (2000) [Pubmed]
  26. Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody-associated cross-reactive idiotypes. Kipps, T.J., Duffy, S.F. J. Clin. Invest. (1991) [Pubmed]
  27. The effect of a 10-day space flight on the function, phenotype, and adhesion molecule expression of splenocytes and lymph node lymphocytes. Grove, D.S., Pishak, S.A., Mastro, A.M. Exp. Cell Res. (1995) [Pubmed]
  28. Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells. Terstappen, L.W., Huang, S., Safford, M., Lansdorp, P.M., Loken, M.R. Blood (1991) [Pubmed]
  29. Simultaneous ligation of CD5 and CD28 on resting T lymphocytes induces T cell activation in the absence of T cell receptor/CD3 occupancy. Verwilghen, J., Vandenberghe, P., Wallays, G., de Boer, M., Anthony, N., Panayi, G.S., Ceuppens, J.L. J. Immunol. (1993) [Pubmed]
  30. Immunophenotyping of non-Hodgkin's lymphoma. Lack of correlation between immunophenotype and cell morphology. Schuurman, H.J., van Baarlen, J., Huppes, W., Lam, B.W., Verdonck, L.F., van Unnik, J.A. Am. J. Pathol. (1987) [Pubmed]
  31. Modulation of cell surface molecules during HIV-1 infection of H9 cells. An immunoelectron microscopic study. Meerloo, T., Parmentier, H.K., Osterhaus, A.D., Goudsmit, J., Schuurman, H.J. AIDS (1992) [Pubmed]
  32. Immobilized anti-CD5 together with prolonged activation of protein kinase C induce interleukin 2-dependent T cell growth: evidence for signal transduction through CD5. Vandenberghe, P., Ceuppens, J.L. Eur. J. Immunol. (1991) [Pubmed]
  33. An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes. Renaudineau, Y., Hillion, S., Saraux, A., Mageed, R.A., Youinou, P. Blood (2005) [Pubmed]
  34. CD5 expression in thymic carcinoma. Hishima, T., Fukayama, M., Fujisawa, M., Hayashi, Y., Arai, K., Funata, N., Koike, M. Am. J. Pathol. (1994) [Pubmed]
  35. Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis. Leandro, M.J., Cambridge, G., Ehrenstein, M.R., Edwards, J.C. Arthritis Rheum. (2006) [Pubmed]
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