Gene Review:
CD5 - CD5 molecule
Homo sapiens
Synonyms:
LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5, T1
- The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck. Raab, M., Yamamoto, M., Rudd, C.E. Mol. Cell. Biol. (1994)
- De novo CD5-positive and Richter's syndrome-associated diffuse large B cell lymphomas are genotypically distinct. Matolcsy, A., Chadburn, A., Knowles, D.M. Am. J. Pathol. (1995)
- Inhibition of synovial fluid T cell proliferation by anti-CD5 monoclonal antibodies. A potential mechanism for their immunotherapeutic action in vivo. Verwilghen, J., Kingsley, G.H., Ceuppens, J.L., Panayi, G.S. Arthritis Rheum. (1992)
- T cell depletion with anti-CD5 immunotoxin in histocompatible bone marrow transplantation. The correlation between residual CD5 negative T cells and subsequent graft-versus-host disease. Filipovich, A.H., Vallera, D., McGlave, P., Polich, D., Gajl-Peczalska, K., Haake, R., Lasky, L., Blazar, B., Ramsay, N.K., Kersey, J. Transplantation (1990)
- Predictors of Parenting Behavior Trajectories Among Families of Young Adolescents with and without Spina Bifida. Greenley, R.N., Holmbeck, G.N., Rose, B.M. Journal of pediatric psychology (2006)
- An affective and cognitive model of marijuana and alcohol problems. Simons, J.S., Carey, K.B. Addictive behaviors. (2006)
- Origins and functions of B-1 cells with notes on the role of CD5. Berland, R., Wortis, H.H. Annu. Rev. Immunol. (2002)
- The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. Van de Velde, H., von Hoegen, I., Luo, W., Parnes, J.R., Thielemans, K. Nature (1991)
- Monoclonal antibodies recognizing CD5, CD10 and CD23 in formalin-fixed, paraffin-embedded tissue: production and assessment of their value in the diagnosis of small B-cell lymphoma. Watson, P., Wood, K.M., Lodge, A., McIntosh, G.G., Milton, I., Piggott, N.H., Proctor, S.J., Taylor, P.R., Smith, S., Jack, F., Bell, H., Steward, M., Anderson, J.J., Horne, C.H., Angus, B. Histopathology (2000)
- Fludarabine induces apoptosis in chronic lymphocytic leukemia--the role of P53, Bcl-2, Bax, Mcl-1, and Bag-1 proteins. Faria, J.R., Yamamoto, M., Faria, R.M., Kerbauy, J., Oliveira, J.S. Braz. J. Med. Biol. Res. (2006)
- Single amino-acid changes in HIV envelope affect viral tropism and receptor binding. Cordonnier, A., Montagnier, L., Emerman, M. Nature (1989)
- Cranial neuropathy heralding otherwise occult AIDS-related large cell lymphoma. Berger, J.R., Flaster, M., Schatz, N., Droller, D., Benedetto, P., Poblete, R., Post, M.J. Journal of clinical neuro-ophthalmology. (1993)
- CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn. Burgess, K.E., Yamamoto, M., Prasad, K.V., Rudd, C.E. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Identification and characterization of circulating human transitional B cells. Sims, G.P., Ettinger, R., Shirota, Y., Yarboro, C.H., Illei, G.G., Lipsky, P.E. Blood (2005)
- CD2 and CD3 associate independently with CD5 and differentially regulate signaling through CD5 in Jurkat T cells. Carmo, A.M., Castro, M.A., Arosa, F.A. J. Immunol. (1999)
- Expression of RAGs in peripheral B cells outside germinal centers is associated with the expression of CD5. Hillion, S., Saraux, A., Youinou, P., Jamin, C. J. Immunol. (2005)
- Rearrangement of T cell receptor beta, gamma, and delta gene loci in human pre-T cell acute lymphoblastic leukemia. Raghavachar, A., Thiel, E., Hansen-Hagge, T.E., Kranz, B., Bartram, C.R. Leukemia (1989)
- Ligation of the CD5 or CD28 molecules on resting human T cells induces expression of the early activation antigen CD69 by a calcium- and tyrosine kinase-dependent mechanism. Vandenberghe, P., Verwilghen, J., Van Vaeck, F., Ceuppens, J.L. Immunology (1993)
- Inhibition of the progression of multiple sclerosis by linomide is associated with upregulation of CD4+/CD45RA+ cells and downregulation of CD4+/CD45RO+ cells. Lehmann, D., Karussis, D., Mizrachi-Koll, R., Linde, A.S., Abramsky, O. Clin. Immunol. Immunopathol. (1997)
- Expression and function of a CD5 cDNA in human and murine T cells. Nishimura, Y., Bierer, B.E., Jones, W.K., Jones, N.H., Strominger, J.L., Burakoff, S.J. Eur. J. Immunol. (1988)
- Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype. Gary-Gouy, H., Sainz-Perez, A., Marteau, J.B., Marfaing-Koka, A., Delic, J., Merle-Beral, H., Galanaud, P., Dalloul, A. J. Immunol. (2007)
- Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes. Gringhuis, S.I., de Leij, L.F., Coffer, P.J., Vellenga, E. Mol. Cell. Biol. (1998)
- Determination of the tyrosine phosphorylation sites in the T cell transmembrane glycoprotein CD5. Dennehy, K.M., Ferris, W.F., Veenstra, H., Zuckerman, L.A., Killeen, N., Beyers, A.D. Int. Immunol. (2001)
- Human interleukin 4 down-regulates the surface expression of CD5 on normal and leukemic B cells. Defrance, T., Vanbervliet, B., Durand, I., Banchereau, J. Eur. J. Immunol. (1989)
- Immunoglobulin A cell distribution in the human small intestine: phenotypic and functional characteristics. Farstad, I.N., Carlsen, H., Morton, H.C., Brandtzaeg, P. Immunology (2000)
- Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody-associated cross-reactive idiotypes. Kipps, T.J., Duffy, S.F. J. Clin. Invest. (1991)
- The effect of a 10-day space flight on the function, phenotype, and adhesion molecule expression of splenocytes and lymph node lymphocytes. Grove, D.S., Pishak, S.A., Mastro, A.M. Exp. Cell Res. (1995)
- Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells. Terstappen, L.W., Huang, S., Safford, M., Lansdorp, P.M., Loken, M.R. Blood (1991)
- Simultaneous ligation of CD5 and CD28 on resting T lymphocytes induces T cell activation in the absence of T cell receptor/CD3 occupancy. Verwilghen, J., Vandenberghe, P., Wallays, G., de Boer, M., Anthony, N., Panayi, G.S., Ceuppens, J.L. J. Immunol. (1993)
- Immunophenotyping of non-Hodgkin's lymphoma. Lack of correlation between immunophenotype and cell morphology. Schuurman, H.J., van Baarlen, J., Huppes, W., Lam, B.W., Verdonck, L.F., van Unnik, J.A. Am. J. Pathol. (1987)
- Modulation of cell surface molecules during HIV-1 infection of H9 cells. An immunoelectron microscopic study. Meerloo, T., Parmentier, H.K., Osterhaus, A.D., Goudsmit, J., Schuurman, H.J. AIDS (1992)
- Immobilized anti-CD5 together with prolonged activation of protein kinase C induce interleukin 2-dependent T cell growth: evidence for signal transduction through CD5. Vandenberghe, P., Ceuppens, J.L. Eur. J. Immunol. (1991)
- An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes. Renaudineau, Y., Hillion, S., Saraux, A., Mageed, R.A., Youinou, P. Blood (2005)
- CD5 expression in thymic carcinoma. Hishima, T., Fukayama, M., Fujisawa, M., Hayashi, Y., Arai, K., Funata, N., Koike, M. Am. J. Pathol. (1994)
- Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis. Leandro, M.J., Cambridge, G., Ehrenstein, M.R., Edwards, J.C. Arthritis Rheum. (2006)