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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Chicken coagulation factor XIIIA is produced by the theca externa and stabilizes the ovarian follicular wall.

Development of the follicle in egg-laying species such as the chicken is regulated by systemic factors as well as by the highly orchestrated interplay of differentially expressed genes within this organ. Differential mRNA display analysis of defined phases of follicle development resulted in the characterization of coagulation factor XIIIA. It is expressed and produced by cells of the theca externa in a highly regulated manner during distinct growth phases of the follicle. Transcripts for factor XIIIA are already detectable at the beginning of follicle development and peak at the end of phase 2. Protein levels, however, still increase during phase 3, peak shortly after ovulation, and persist until the postovulatory tissue is completely resorbed. Factor XIIIA is secreted as a monomer into the extracellular matrix of the theca externa and is not associated with factor XIIIB as is the case in plasma. Our data suggest that, due to its transglutaminase activity, factor XIIIA stabilizes the follicular wall by cross-linking matrix components. Thus, coagulation factor XIIIA might play a key role in coping with the massive mechanical stress exerted by the large amount of yolk accumulating during the rapid growth phase of the oocyte.[1]


  1. Chicken coagulation factor XIIIA is produced by the theca externa and stabilizes the ovarian follicular wall. Recheis, B., Osanger, A., Haubenwallner, S., Schneider, W.J., Nimpf, J. J. Biol. Chem. (2000) [Pubmed]
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