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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Stress, Mechanical

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Disease relevance of Stress, Mechanical


High impact information on Stress, Mechanical


Chemical compound and disease context of Stress, Mechanical

  • The 10% and 20% dietary xylitol supplementation significantly prevented the type I diabetes-induced decrease in the mechanical stress resistance of the tibia in the three-point bending test, the shear stress of the femur in the torsion test, and the stress resistance of the femoral neck in the loading test [10].
  • Various potential contributors to the inflammatory response in the vessel wall include atherogenic lipids, mechanical stress and injury, hypertension and angiotensin II, cigarette smoking, immune response to neoantigens, and chronic infections with viruses and or bacteria (Table 1) [11].
  • We propose that, in addition to mechanical stress, the rise of estrogen toward the end of pregnancy contributes to pregnancy-related heart hypertrophy by increased c-Src activity and that the rise of estrogen is one factor that down regulates cardiac Kv4.3 gene expression providing a molecular correlate for a longer QT interval in pregnancy [12].
  • In addition, it is conceivable that, under certain pathophysiological conditions (e.g., ischemia or excessive mechanical stress), the sensitivity of the channels could be altered in such a way that the conductance opens even in the presence of physiological Ca(2+), Mg(2+), and insulin [13].
  • These findings suggest that aging in both HGF and HPLF may be an important factor in the severity of periodontal disease through higher production of inflammatory mediators in response to both LPS and mechanical stress [14].

Biological context of Stress, Mechanical


Anatomical context of Stress, Mechanical


Associations of Stress, Mechanical with chemical compounds

  • Here we show that mechanical stresses applied to the cell surface alter the cyclic AMP signalling cascade and downstream gene transcription by modulating local release of signals generated by activated integrin receptors in a G-protein-dependent manner, whereas distortion of integrins in the absence of receptor occupancy has no effect [24].
  • Here we show that the AT1 receptor can be activated by mechanical stress through an angiotensin-II-independent mechanism [9].
  • The structure reveals unusual features in the SP domain and provides strong support for the hypothesis that C1r activation in C1 is triggered by a mechanical stress caused by target recognition that disrupts the CCP1-SP interfaces and allows formation of transient states involving important conformational changes [16].
  • Gene-specific probes were constructed to examine the expression of transcripts encoding the two ACC synthase isoforms under two conditions of enhanced ethylene formation--namely, during fruit ripening and in response to mechanical stress (wounding) [25].
  • Interestingly, these non-CRAC channels are selectively activated by mechanical stress, although the mechanism overlaps with BCR-activated pathways, suggesting that they may operate in concert to produce functionally diverse Ca(2+) signals [26].

Gene context of Stress, Mechanical

  • The tissue-specific expression of TCH3 suggests that expression may be regulated not only by externally applied mechanical stimuli but also by mechanical stresses generated during development [27].
  • Lack of plakoglobin affects the number and structure of desmosomes, resulting in visible defects when cells are subjected to increasing mechanical stress, e.g. when embryonic blood starts circulating or during skin differentiation [28].
  • These data link alterations in the microtubule and actin cytoskeleton to the expression of CTGF and provide a molecular basis for the observation that CTGF is up-regulated in cells exposed to mechanical stress [29].
  • Suramin, a growth factor receptor antagonist, completely abolished ERK activation, significantly blocked MKP-1 expression, but not JNK/SAPK and p38 MAPK activation, in response to mechanical stress [30].
  • Herein, we provide evidence that VSMC responses to mechanical stress also include induction of MAPK phosphatase-1 (MKP-1), which may serve as a negative regulator of MAPK signaling pathways [30].

Analytical, diagnostic and therapeutic context of Stress, Mechanical


  1. Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Sano, M., Abdellatif, M., Oh, H., Xie, M., Bagella, L., Giordano, A., Michael, L.H., DeMayo, F.J., Schneider, M.D. Nat. Med. (2002) [Pubmed]
  2. Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin. Ishijima, M., Rittling, S.R., Yamashita, T., Tsuji, K., Kurosawa, H., Nifuji, A., Denhardt, D.T., Noda, M. J. Exp. Med. (2001) [Pubmed]
  3. Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. Pradervand, S., Yasukawa, H., Muller, O.G., Kjekshus, H., Nakamura, T., St Amand, T.R., Yajima, T., Matsumura, K., Duplain, H., Iwatate, M., Woodard, S., Pedrazzini, T., Ross, J., Firsov, D., Rossier, B.C., Hoshijima, M., Chien, K.R. EMBO J. (2004) [Pubmed]
  4. N-methylethanolamine attenuates cardiac fibrosis and improves diastolic function: inhibition of phospholipase D as a possible mechanism. Yamamoto, K., Takahashi, Y., Mano, T., Sakata, Y., Nishikawa, N., Yoshida, J., Oishi, Y., Hori, M., Miwa, T., Inoue, S., Masuyama, T. Eur. Heart J. (2004) [Pubmed]
  5. Cervical discs are most susceptible to beta 2-microglobulin amyloid deposition in the vertebral column. Ohashi, K., Hara, M., Kawai, R., Ogura, Y., Honda, K., Nihei, H., Mimura, N. Kidney Int. (1992) [Pubmed]
  6. Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor. Jankowski, V., Tölle, M., Vanholder, R., Schönfelder, G., van der Giet, M., Henning, L., Schlüter, H., Paul, M., Zidek, W., Jankowski, J. Nat. Med. (2005) [Pubmed]
  7. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Brancaccio, M., Fratta, L., Notte, A., Hirsch, E., Poulet, R., Guazzone, S., De Acetis, M., Vecchione, C., Marino, G., Altruda, F., Silengo, L., Tarone, G., Lembo, G. Nat. Med. (2003) [Pubmed]
  8. Role of integrins in cellular responses to mechanical stress and adhesion. Shyy, J.Y., Chien, S. Curr. Opin. Cell Biol. (1997) [Pubmed]
  9. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Zou, Y., Akazawa, H., Qin, Y., Sano, M., Takano, H., Minamino, T., Makita, N., Iwanaga, K., Zhu, W., Kudoh, S., Toko, H., Tamura, K., Kihara, M., Nagai, T., Fukamizu, A., Umemura, S., Iiri, T., Fujita, T., Komuro, I. Nat. Cell Biol. (2004) [Pubmed]
  10. Dietary xylitol supplementation prevents osteoporotic changes in streptozotocin-diabetic rats. Mattila, P.T., Knuuttila, M.L., Svanberg, M.J. Metab. Clin. Exp. (1998) [Pubmed]
  11. Chronic infections and atherosclerosis/thrombosis. Shah, P.K. Current atherosclerosis reports. (2002) [Pubmed]
  12. Molecular and functional signature of heart hypertrophy during pregnancy. Eghbali, M., Deva, R., Alioua, A., Minosyan, T.Y., Ruan, H., Wang, Y., Toro, L., Stefani, E. Circ. Res. (2005) [Pubmed]
  13. Nonselective cation current in rabbit ventricular myocytes. Song, Y.D., Yang, X.C., Liu, T.F., Gu, Z.W. Methods and findings in experimental and clinical pharmacology. (2005) [Pubmed]
  14. Effect of aging on functional changes of periodontal tissue cells. Abiko, Y., Shimizu, N., Yamaguchi, M., Suzuki, H., Takiguchi, H. Ann. Periodontol. (1998) [Pubmed]
  15. Impaired flow-induced dilation in mesenteric resistance arteries from mice lacking vimentin. Henrion, D., Terzi, F., Matrougui, K., Duriez, M., Boulanger, C.M., Colucci-Guyon, E., Babinet, C., Briand, P., Friedlander, G., Poitevin, P., Lévy, B.I. J. Clin. Invest. (1997) [Pubmed]
  16. The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex. Budayova-Spano, M., Lacroix, M., Thielens, N.M., Arlaud, G.J., Fontecilla-Camps, J.C., Gaboriaud, C. EMBO J. (2002) [Pubmed]
  17. LeMPK3 is a mitogen-activated protein kinase with dual specificity induced during tomato defense and wounding responses. Mayrose, M., Bonshtien, A., Sessa, G. J. Biol. Chem. (2004) [Pubmed]
  18. Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells. Klein-Nulend, J., Burger, E.H., Semeins, C.M., Raisz, L.G., Pilbeam, C.C. J. Bone Miner. Res. (1997) [Pubmed]
  19. Differential adhesion leads to segregation and exclusion of N-cadherin-deficient cells in chimeric embryos. Kostetskii, I., Moore, R., Kemler, R., Radice, G.L. Dev. Biol. (2001) [Pubmed]
  20. Role of transiently altered sarcolemmal membrane permeability and basic fibroblast growth factor release in the hypertrophic response of adult rat ventricular myocytes to increased mechanical activity in vitro. Kaye, D., Pimental, D., Prasad, S., Mäki, T., Berger, H.J., McNeil, P.L., Smith, T.W., Kelly, R.A. J. Clin. Invest. (1996) [Pubmed]
  21. Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells. Yasuda, T., Kondo, S., Homma, T., Harris, R.C. J. Clin. Invest. (1996) [Pubmed]
  22. Tensegrity: the architectural basis of cellular mechanotransduction. Ingber, D.E. Annu. Rev. Physiol. (1997) [Pubmed]
  23. Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. Yoshigi, M., Hoffman, L.M., Jensen, C.C., Yost, H.J., Beckerle, M.C. J. Cell Biol. (2005) [Pubmed]
  24. Mechanical control of cyclic AMP signalling and gene transcription through integrins. Meyer, C.J., Alenghat, F.J., Rim, P., Fong, J.H., Fabry, B., Ingber, D.E. Nat. Cell Biol. (2000) [Pubmed]
  25. Differential expression of two genes for 1-aminocyclopropane-1-carboxylate synthase in tomato fruits. Olson, D.C., White, J.A., Edelman, L., Harkins, R.N., Kende, H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  26. Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli. Liu, Q.H., Liu, X., Wen, Z., Hondowicz, B., King, L., Monroe, J., Freedman, B.D. J. Immunol. (2005) [Pubmed]
  27. Arabidopsis TCH3 encodes a novel Ca2+ binding protein and shows environmentally induced and tissue-specific regulation. Sistrunk, M.L., Antosiewicz, D.M., Purugganan, M.M., Braam, J. Plant Cell (1994) [Pubmed]
  28. Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice. Bierkamp, C., Schwarz, H., Huber, O., Kemler, R. Development (1999) [Pubmed]
  29. Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton. Ott, C., Iwanciw, D., Graness, A., Giehl, K., Goppelt-Struebe, M. J. Biol. Chem. (2003) [Pubmed]
  30. Cyclic strain stress-induced mitogen-activated protein kinase (MAPK) phosphatase 1 expression in vascular smooth muscle cells is regulated by Ras/Rac-MAPK pathways. Li, C., Hu, Y., Mayr, M., Xu, Q. J. Biol. Chem. (1999) [Pubmed]
  31. FHL2 (SLIM3) is not essential for cardiac development and function. Chu, P.H., Bardwell, W.M., Gu, Y., Ross, J., Chen, J. Mol. Cell. Biol. (2000) [Pubmed]
  32. Visualization of elementary mechanosensitive Ca2+-influx events, Ca2+ spots, in bovine lens epithelial cells. Ohata, H., Tanaka , K., Maeyama, N., Yamamoto, M., Momose, K. J. Physiol. (Lond.) (2001) [Pubmed]
  33. Role of prostaglandin I2 in the gene expression induced by mechanical stress in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament. Ohishi, H., Furukawa, K., Iwasaki, K., Ueyama, K., Okada, A., Motomura, S., Harata, S., Toh, S. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  34. Influence of stress on calcification of delipidated bovine pericardial tissue employed in construction of cardiac valves. Jorge-Herrero, E., Fernández, P., Escudero, C., de la Torre, N., Zurita M García Páez, J.M., Castillo-Olivares, J.L. J. Biomed. Mater. Res. (1996) [Pubmed]
  35. Regulation of alpha7 integrin by mechanical stress during skeletal muscle regeneration. Kääriäinen, M., Liljamo, T., Pelto-Huikko, M., Heino, J., Järvinen, M., Kalimo, H. Neuromuscul. Disord. (2001) [Pubmed]
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