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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier.

Asymmetric localization of proteins plays a key role in many cellular processes, including cell polarity and cell fate determination. Using DNA microarray analysis, we identified a plasma membrane protein-encoding mRNA (IST2) that is transported to the bud tip by an actomyosin-based process. mRNA localization created a higher concentration of IST2 protein in the bud compared with that of the mother cell, and this asymmetry was maintained by a septin-mediated membrane diffusion barrier at the mother-bud neck. These results indicate that yeast creates distinct plasma membrane compartments, as has been described in neurons and epithelial cells.[1]

References

  1. Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier. Takizawa, P.A., DeRisi, J.L., Wilhelm, J.E., Vale, R.D. Science (2000) [Pubmed]
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