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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Review article: the control of gastric acid and Helicobacter pylori eradication.

This review focuses on the gastric acid pump as a therapeutic target for the control of acid secretion in peptic ulcer and gastro-oesophageal reflux disease. The mechanism of the proton pump inhibitors is discussed as well as their clinical use. The biology of Helicobacter pylori as a gastric denizen is then discussed, with special regard to its mechanisms of acid resistance. Here the properties of the products of the urease gene clusters, ureA, B and ureI, E, F, G and H are explored in order to explain the unique location of this pathogen. The dominant requirement for acid resistance is the presence of a proton gated urea transporter, UreI, which increases access of gastric juice urea to the intrabacterial urease 300-fold. This enables rapid and continuous buffering of the bacterial periplasm to approximately pH 6.0, allowing acid resistance and growth at acidic pH in the presence of 1 mM urea. A hypothesis for the basis of combination therapy for eradication is also presented.[1]


  1. Review article: the control of gastric acid and Helicobacter pylori eradication. Sachs, G., Shin, J.M., Munson, K., Vagin, O., Lambrecht, N., Scott, D.R., Weeks, D.L., Melchers, K. Aliment. Pharmacol. Ther. (2000) [Pubmed]
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