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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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MR spectroscopy study of dichloroacetate treatment after ischemic stroke.

In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.[1]

References

  1. MR spectroscopy study of dichloroacetate treatment after ischemic stroke. Graham, G.D., Barker, P.B., Brooks, W.M., Morris, D.C., Ahmed, W., Bryniarski, E., Hearshen, D.O., Sanders, J.A., Holshouser, B.A., Turkel, C.C. Neurology (2000) [Pubmed]
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