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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

CP6679, a new injectable cephalosporin. Part 1: synthesis and structure-activity relationships.

A series of cephalosporins bearing a 5,5-fused ring system, an (imidazo[5,1-b]thiazolium-6-yl)methyl group, at the C-3 position were synthesized and evaluated for in vitro antibacterial activities. CP6679 (1s) and its analogues showed potent antibacterial activities against gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa. They were also highly active against methicillin-resistant Staphylococcus aureus (MRSA). CP6679 (1s) showed more potent antibacterial activity than ceftazidime (CAZ) or cefpirome (CPR) against Pseudomonas aeruginosa and MRSA.[1]

References

  1. CP6679, a new injectable cephalosporin. Part 1: synthesis and structure-activity relationships. Masakitsushima, n.u.l.l., Iwamatsu, K., Umemura, E., Kudo, T., Sato, Y., Shiokawa, S., Takizawa, H., Kano, Y., Kobayashi, K., Ida, T., Tamura, A., Atsumi, K. Bioorg. Med. Chem. (2000) [Pubmed]
 
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