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MeSH Review


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Disease relevance of Gastritis


Psychiatry related information on Gastritis

  • The markers for gastritis did not contribute to an elucidation of a possible connection between this condition, dementia disorders, or cobalamin/folate deficiency [6].
  • It is concluded that alcohol, nicotine, drug abuse and various diseases do not play an important role in the frequency of occurrence of gastritis [7].
  • The incidence appears to be increasing in Zimbabwe. There was no significant difference between ulcer patients and controls in their association with alcohol consumption, cigarette smoking, urban residence and salicylate ingestion (p > 0.1), Ulceration was most strongly associated with H pylori gastritis compared to control (p < 0.001) [8].

High impact information on Gastritis

  • After 12 months, gastritis had healed in 75.0 percent of the patients in the group given omeprazole and antibiotics and in 3.0 percent of the patients in the omeprazole group (P<0.001); the respective rates of H. pylori eradication were 79 percent and 2 percent [9].
  • Autoantibodies to gastrin-producing cells in antral (type B) chronic gastritis [10].
  • The short-term risk of erosive gastritis was greater for aspirin than fenoprofen [11].
  • The wild-type and vacA mutants induced severe gastritis, whereas cagE mutants induced far milder changes [12].
  • The potential role of CD95-mediated apoptosis was investigated in a panel of gastric biopsies obtained from patients with H. pylori-associated chronic gastritis (n = 29) and with noninfected normal mucosa (n = 10) [13].

Chemical compound and disease context of Gastritis


Biological context of Gastritis


Anatomical context of Gastritis


Gene context of Gastritis

  • Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis [22].
  • CONCLUSIONS: Our results suggest that H. pylori interacts with MUC1 and that there are functional allelic differences that affect susceptibility to gastritis [28].
  • A possible involvement of Fas-Fas ligand signaling in the pathogenesis of murine autoimmune gastritis [29].
  • Here, we examined TGF-beta 1 signaling in Hp-associated gastritis [30].
  • Here, we present the characterization of two mouse lines carrying mutant alleles of the gene encoding the Kcnq1 potassium channel, which very rapidly establish chronic gastritis in a pathogen-exposed environment [31].
  • CD39 and CD73 expressed by Th cells contribute to local accumulation of adenosine and attenuation of gastritis, which may favor persistent infection [32].

Analytical, diagnostic and therapeutic context of Gastritis


  1. Molecular mimicry between Helicobacter pylori antigens and H+, K+ --adenosine triphosphatase in human gastric autoimmunity. Amedei, A., Bergman, M.P., Appelmelk, B.J., Azzurri, A., Benagiano, M., Tamburini, C., van der Zee, R., Telford, J.L., Vandenbroucke-Grauls, C.M., D'Elios, M.M., Del Prete, G. J. Exp. Med. (2003) [Pubmed]
  2. BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma. Mazzucchelli, L., Blaser, A., Kappeler, A., Schärli, P., Laissue, J.A., Baggiolini, M., Uguccioni, M. J. Clin. Invest. (1999) [Pubmed]
  3. Mast cell involvement in gastritis with or without Helicobacter pylori infection. Nakajima, S., Krishnan, B., Ota, H., Segura, A.M., Hattori, T., Graham, D.Y., Genta, R.M. Gastroenterology (1997) [Pubmed]
  4. Chronic antral gastritis in duodenal ulcer. Natural history and treatment with prostaglandin E1. Hui, W.M., Lam, S.K., Ho, J., Ng, M.M., Lui, I., Lai, C.L., Lok, A.S., Lau, W.Y., Poon, G.P., Choi, S. Gastroenterology (1986) [Pubmed]
  5. Location, healing, and recurrence of gastric ulcers in relation to fundal gastritis. Tatsuta, M., Okuda, S. Gastroenterology (1975) [Pubmed]
  6. Cobalamin, folate, methylmalonic acid, homocysteine, and gastritis markers in dementia. Nägga, K., Rajani, R., Mårdh, E., Borch, K., Mårdh, S., Marcusson, J. Dementia and geriatric cognitive disorders. (2003) [Pubmed]
  7. The role of certain habits and various diseases in the occurrence of gastritis. Massarrat, S., Paidlik, A., Pittner, P., Schmitz-Moormann, P., Wurbs, M. Hepatogastroenterology (1983) [Pubmed]
  8. Prospective endoscopic study of duodenal ulcer in Zimbabwean Blacks. Gangaidzo, I., Kiire, C., Mason, P., Sitima, J., Gwanzura, L. The Central African journal of medicine. (1992) [Pubmed]
  9. Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment (OCAY) Study Group. Blum, A.L., Talley, N.J., O'Moráin, C., van Zanten, S.V., Labenz, J., Stolte, M., Louw, J.A., Stubberöd, A., Theodórs, A., Sundin, M., Bolling-Sternevald, E., Junghard, O. N. Engl. J. Med. (1998) [Pubmed]
  10. Autoantibodies to gastrin-producing cells in antral (type B) chronic gastritis. Vandelli, C., Bottazzo, G.F., Doniach, D., Franceschi, F. N. Engl. J. Med. (1979) [Pubmed]
  11. Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. Loebl, D.H., Craig, R.M., Culic, D.D., Ridolfo, A.S., Falk, J., Schmid, F.R. JAMA (1977) [Pubmed]
  12. Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. Ogura, K., Maeda, S., Nakao, M., Watanabe, T., Tada, M., Kyutoku, T., Yoshida, H., Shiratori, Y., Omata, M. J. Exp. Med. (2000) [Pubmed]
  13. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. Rudi, J., Kuck, D., Strand, S., von Herbay, A., Mariani, S.M., Krammer, P.H., Galle, P.R., Stremmel, W. J. Clin. Invest. (1998) [Pubmed]
  14. Acute treatment of severe haemorrhagic gastritis with high-dose sucralfate. Tryba, M., May, B. Lancet (1988) [Pubmed]
  15. Gastritis and cimetidine: A possible explanation. Nicholls, P.E., Henry, K. Lancet (1978) [Pubmed]
  16. Ascorbic acid in the human stomach. Sobala, G.M., Schorah, C.J., Sanderson, M., Dixon, M.F., Tompkins, D.S., Godwin, P., Axon, A.T. Gastroenterology (1989) [Pubmed]
  17. Lithium chloride: protective and antisecretory properties in rats. Wong, R.K., Boedeker, B., Hickey, T.M., Wilkinson, D.S., Johnson, L.F. Gastroenterology (1984) [Pubmed]
  18. Autoimmune gastritis in type 1 diabetes: a clinically oriented review. De Block, C.E., De Leeuw, I.H., Van Gaal, L.F. J. Clin. Endocrinol. Metab. (2008) [Pubmed]
  19. An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus. Alderuccio, F., Toh, B.H., Tan, S.S., Gleeson, P.A., van Driel, I.R. J. Exp. Med. (1993) [Pubmed]
  20. Influence of inflammation and atrophy on pancreatic secretory trypsin inhibitor levels within the gastric mucosa. Playford, R.J., Hanby, A.M., Quinn, C., Calam, J. Gastroenterology (1994) [Pubmed]
  21. Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice. Fox, J.G., Li, X., Cahill, R.J., Andrutis, K., Rustgi, A.K., Odze, R., Wang, T.C. Gastroenterology (1996) [Pubmed]
  22. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Fu, S., Ramanujam, K.S., Wong, A., Fantry, G.T., Drachenberg, C.B., James, S.P., Meltzer, S.J., Wilson, K.T. Gastroenterology (1999) [Pubmed]
  23. Long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth, and gastritis. Lamberts, R., Creutzfeldt, W., Strüber, H.G., Brunner, G., Solcia, E. Gastroenterology (1993) [Pubmed]
  24. Endogenous prostaglandin E2 in gastric mucosa of patients with alcoholic cirrhosis and portal hypertension. Arakawa, T., Satoh, H., Fukuda, T., Nakamura, H., Kobayashi, K. Gastroenterology (1987) [Pubmed]
  25. Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Zavros, Y., Rieder, G., Ferguson, A., Samuelson, L.C., Merchant, J.L. Gastroenterology (2002) [Pubmed]
  26. Fas/CD95 is required for gastric mucosal damage in autoimmune gastritis. Marshall, A.C., Alderuccio, F., Toh, B.H. Gastroenterology (2002) [Pubmed]
  27. How does Helicobacter pylori cause mucosal damage? Its effect on acid and gastrin physiology. Calam, J., Gibbons, A., Healey, Z.V., Bliss, P., Arebi, N. Gastroenterology (1997) [Pubmed]
  28. Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis. Vinall, L.E., King, M., Novelli, M., Green, C.A., Daniels, G., Hilkens, J., Sarner, M., Swallow, D.M. Gastroenterology (2002) [Pubmed]
  29. A possible involvement of Fas-Fas ligand signaling in the pathogenesis of murine autoimmune gastritis. Nishio, A., Katakai, T., Oshima, C., Kasakura, S., Sakai, M., Yonehara, S., Suda, T., Nagata, S., Masuda, T. Gastroenterology (1996) [Pubmed]
  30. Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection. Monteleone, G., Del Vecchio Blanco, G., Palmieri, G., Vavassori, P., Monteleone, I., Colantoni, A., Battista, S., Spagnoli, L.G., Romano, M., Borrelli, M., MacDonald, T.T., Pallone, F. Gastroenterology (2004) [Pubmed]
  31. Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice. Elso, C.M., Lu, X., Culiat, C.T., Rutledge, J.C., Cacheiro, N.L., Generoso, W.M., Stubbs, L.J. Hum. Mol. Genet. (2004) [Pubmed]
  32. CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice. Alam, M.S., Kurtz, C.C., Rowlett, R.M., Reuter, B.K., Wiznerowicz, E., Das, S., Linden, J., Crowe, S.E., Ernst, P.B. J. Infect. Dis. (2009) [Pubmed]
  33. Pseudo-Zollinger--Ellison syndrome in a child presenting with anemia. Zaatar, R., Younoszai, M.K., Mitros, F. Gastroenterology (1987) [Pubmed]
  34. Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. Nomura, S., Baxter, T., Yamaguchi, H., Leys, C., Vartapetian, A.B., Fox, J.G., Lee, J.R., Wang, T.C., Goldenring, J.R. Gastroenterology (2004) [Pubmed]
  35. Sucralfate therapy in patients with symptoms of alkaline reflux gastritis. A randomized, double-blind study. Buch, K.L., Weinstein, W.M., Hill, T.A., Elashoff, J.D., Reedy, T.J., Ippoliti, A.F., Tedesco, F.J., Singh, M. Am. J. Med. (1985) [Pubmed]
  36. The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. Ohyauchi, M., Imatani, A., Yonechi, M., Asano, N., Miura, A., Iijima, K., Koike, T., Sekine, H., Ohara, S., Shimosegawa, T. Gut (2005) [Pubmed]
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