Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Dornhoffer, J.L. et al.

Prognostic factors in ossiculoplasty: a statistical staging system.

OBJECTIVE: To determine factors that predict hearing results using a standard prosthesis system. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary referral center. PATIENTS: All patients undergoing ossiculoplasty with the Dornhoffer HAPEX partial and total ossicular replacement prostheses (PORP and TORP) from February 1995 to May 1999 who had documented postoperative follow-up and no congenital atresia or stapes fixation. A total of 185 patients (200 ears), 105 men and 80 women, were evaluated. INTERVENTIONS: Ossiculoplasty with the Dornhoffer prostheses. MAIN OUTCOME MEASURES: Hearing results using a four-frequency pure-tone average air-bone gap ( PTA- ABG). Multivariate statistical analysis determined the effect of mucosal status, ossicular chain status, and type of reconstruction techniques on hearing. RESULTS: The PTA-ABGs were 13.4+/-8.1 dB and 14.0+/-8.4 dB for the PORPs (n = 114) and TORPs (n = 86), respectively, which was not statistically different. When the malleus handle was present (n = 126), the PTA- ABG was 11.6+/-6.2 dB, compared with 16.9+/-10.1 dB when it was absent (n = 74), which was statistically significant (p < 0.05). Mucosal fibrosis, drainage, revision ear surgery, and type of surgical procedure had a significant detrimental impact on hearing. The type of pathologic process (perforation vs. cholesteatoma) had no significant impact on hearing results. CONCLUSIONS: The revised staging system, the Ossiculoplasty Outcome Parameter Staging Index, more adequately predicts hearing outcome in this series of 200 cases.[1]

References

Prognostic factors in ossiculoplasty: a statistical staging system. Dornhoffer, J.L., Gardner, E. Otol. Neurotol. (2001) [Pubmed]

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