The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

TOR2A  -  torsin family 2, member A

Homo sapiens

Synonyms: FLJ14771, TORP1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TOR2A

 

High impact information on TOR2A

  • Main outcome measures were mean postoperative air-bone gap (ABG), proportion achieving ABG closure to <20 dB and <30 dB for group 1 and group 2 overall and when controlling for type of mastoid cavity created (open or closed) and the status of the stapes suprastructure (TORP vs. PORP OCR) [4].
  • NIHs are good prostheses when the stapes is intact, but they are inferior to the TORP when placed on the footplate [5].
  • A comparison of PORP, TORP, and incus homograft for ossicular reconstruction in chronic ear surgery [5].
  • Use of autograft and homograft TORP and PORP in the reconstruction of the conductive system in the middle ear [6].
  • Reconstruction of hearing when malleus is absent: TORP vs. homograft TMMI [7].
 

Biological context of TOR2A

  • "How I do it" - otology and neurotology. A specific issue and its solution. An alternative way of using TORP and PORP [8].
  • Inner ear damage in TORP-operated ears: experimental study on danger from environmental air pressure changes [9].
 

Anatomical context of TOR2A

  • Primary causes of failure of the TORP were instability with migration off the stapes footplate, protrusion or extrusion through the TM and finally, long-term softening and bending secondary to biodegradation of the Plastipore [7].
  • Middle ear reconstruction using cartilage and TORP and PORP [10].
  • Forty-six patients were reconstructed with a homograft TMMI and 38 with cartilage covered TORP and underlay fascia technique; 4.5 years postoperatively, 84% of those patients reconstructed with a homograft TMMI maintained an average A/B gap of 25 dB or better [7].
  • Prosthesis extrusion, the cause of failure in less than 5% of 446 TORP and PORP operations, usually was the result of a mucous membrane or eustachian tube problem [11].
 

Associations of TOR2A with chemical compounds

  • Between September 1998 and October 2000, 23 titanium middle ear implants (23 TORP) were used for reconstruction of the ossicular chain after tympanomastoidectomy [12].
  • For each of four implant designs (incus, incus-stapes, PORP, and TORP), the head is constructed from hydroxylapatite and the shaft from Plasti-Pore [13].
 

Analytical, diagnostic and therapeutic context of TOR2A

  • Success for TORP reconstruction was assessed as air-bone gap closure to within 30 dB and for PORP, to within 20 dB [2].
  • Hearing results with total and partial Plastipore ossicular replacement prostheses (TORP and PORP) were evaluated in open- and closed-cavity operations [14].
  • Closure of the air-bone gap at this frequency to within 10 dB was achieved in 87% of type I tympanoplasties, 73% of type III (PORP), and 70% of type III (TORP) tympanoplasties [15].
  • A similar group of 38 patients presenting with absent malleus, incus, and stapes were reconstructed with isograft temporalis fascia and a cartilage covered TORP [16].

References

  1. Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities. Shichiri, M., Ishimaru, S., Ota, T., Nishikawa, T., Isogai, T., Hirata, Y. Nat. Med. (2003) [Pubmed]
  2. Ossicular chain reconstruction: the TORP and PORP in chronic ear disease. Jackson, C.G., Glasscock, M.E., Schwaber, M.K., Nissen, A.J., Christiansen, S.G., Smith, P.G. Laryngoscope (1983) [Pubmed]
  3. Surgical pathology of middle ear implants. Schuknecht, H.F., Shi, S.R. Laryngoscope (1985) [Pubmed]
  4. Should ossicular reconstruction be staged following tympanomastoidectomy. Kim, H.H., Battista, R.A., Kumar, A., Wiet, R.J. Laryngoscope (2006) [Pubmed]
  5. A comparison of PORP, TORP, and incus homograft for ossicular reconstruction in chronic ear surgery. Silverstein, H., McDaniel, A.B., Lichtenstein, R. Laryngoscope (1986) [Pubmed]
  6. Use of autograft and homograft TORP and PORP in the reconstruction of the conductive system in the middle ear. Betow, C. The American journal of otology. (1985) [Pubmed]
  7. Reconstruction of hearing when malleus is absent: TORP vs. homograft TMMI. Lesinski, S.G. Laryngoscope (1984) [Pubmed]
  8. "How I do it" - otology and neurotology. A specific issue and its solution. An alternative way of using TORP and PORP. Palva, T. Laryngoscope (1981) [Pubmed]
  9. Inner ear damage in TORP-operated ears: experimental study on danger from environmental air pressure changes. Pau, H.W. The Annals of otology, rhinology, and laryngology. (1999) [Pubmed]
  10. Middle ear reconstruction using cartilage and TORP and PORP. Kinney, S.E. Laryngoscope (1979) [Pubmed]
  11. TORPs and PORPs: causes of failure--a report on 446 operations. Sheehy, J.L. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1984) [Pubmed]
  12. Preliminary functional results of tympanoplasty with titanium prostheses. Menéndez-Colino, L.M., Bernal-Sprekelsen, M., Alobid, I., Traserra-Coderch, J. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (2004) [Pubmed]
  13. Hydroxylapatite ossicular replacement prostheses: a four-year experience. Goldenberg, R.A. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1992) [Pubmed]
  14. Functional results of Plastipore prostheses for middle ear ossicular chain reconstruction. Bayazit, Y., Göksu, N., Beder, L. Laryngoscope (1999) [Pubmed]
  15. Composite autograft "shield" reconstruction of remnant tympanic membranes. Duckert, L.G., Müller, J., Makielski, K.H., Helms, J. The American journal of otology. (1995) [Pubmed]
  16. Homograft tympanoplasty in perspective. A long-term clinical-histologic study of formalin-fixed tympanic membranes used for the reconstruction of 125 severely damaged middle ears. Lesinski, S.G. Laryngoscope (1983) [Pubmed]
 
WikiGenes - Universities