Intracellular antibody neutralizes Listeria growth.
We previously reported that treatment of mice with a neutralizing mAb against listeriolysin O ( LLO), the pore-forming toxin of Listeria monocytogenes, provided resistance to this intracellular bacterium. We evaluated whether anti- LLO mAb would affect Listeria handling by macrophages, essential cells in Listeria resistance. Macrophages infected in the presence of anti- LLO mAb showed a marked reduction in intracellular Listeria growth, with a concomitant block in LLO-dependent Listeria passage from phagosome to cytosol. Anti- LLO mAb did not opsonize Listeria but, rather, acted within macrophages to neutralize LLO. Importantly, anti- LLO mAb effects on Listeria growth were independent of Fcgamma receptor expression, IFNgamma signaling, and production of nitric oxide and superoxide. These results identify a novel mechanism for antibody control of bacteria within macrophages.[1]References
- Intracellular antibody neutralizes Listeria growth. Edelson, B.T., Unanue, E.R. Immunity (2001) [Pubmed]
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