Disease relevance of Lsr1

• The strain distribution pattern (SDP) of this trait obtained in the 13 AXB/BXA RI strains studied suggests that an allelic difference at a major locus (Lr-1) is responsible for the trait of resistance/susceptibility to Listeria [1].

High impact information on Lsr1

• We evaluated whether anti-LLO mAb would affect Listeria handling by macrophages, essential cells in Listeria resistance [2].
• Macrophages, NK cells and neutrophils participate in early stages of Listeria resistance [3].
• Preimmunization, which profoundly augments systemic listeria resistance, had no effect on this increased uterine susceptibility [4].
• The SDP of A and B alleles at the Lr-1 locus was fully concordant with that observed for the Hc locus (controlling the level of the C5 component of complement) [1].
• The reduction in Listeria resistance, which is T cell mediated, contrasts with the fact that no significant changes in T-cell-mediated immunity were observed [5].

Biological context of Lsr1

• Effect of human leukocyte and other tissue dialysates on Listeria resistance and phagocytosis in mice [6].

Anatomical context of Lsr1

• 1. The effect of dialysable transfer factor (TFd), derived from human leukocytes or porcine spleen cells, was measured using Listeria resistance in mice [7].
• The effect of dialyzable transfer factor (TFd) on Listeria resistance was measured by survival studies and by assessing phagocytic capacity of peritoneal macrophages [6].

References