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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Specific tracheal migration is mediated by complementary expression of cell surface proteins.

Migration of the Drosophila tracheal cells relies on cues provided by nearby cells; however, little is known about how these signals specify a migratory path. Here we investigate the role of cell surface proteins in the definition of such a pathway. We have found that the PS1 integrin is required in the tracheal cells of the visceral branch, whereas the PS2 integrin is required in the visceral mesoderm; both integrins are necessary for the spreading of the visceral branch over its substratum. This is the first identification of a cell surface molecule with expression restricted to a subset of tracheal cells that all migrate in a given direction. We have also found that expression of PS1 in the visceral branch is regulated by the genes that direct tracheal cell migration, showing that integrin expression is part of the cell-fate program that they specify. These results support a model in which signal transduction determines the tracheal migratory pathways by regulating the expression of cell surface proteins, which in turn interact with surface molecules on the surrounding cell population.[1]


  1. Specific tracheal migration is mediated by complementary expression of cell surface proteins. Boube, M., Martin-Bermudo, M.D., Brown, N.H., Casanova, J. Genes Dev. (2001) [Pubmed]
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