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Gene Review

mew  -  multiple edematous wings

Drosophila melanogaster

Synonyms: CG1771, CT5254, Dmel\CG1771, Integrin alpha-PS1, ItgalphaPS1, ...
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Psychiatry related information on mew


High impact information on mew


Biological context of mew


Anatomical context of mew

  • The functions of PS1 and PS2 are specific in the two tissues, endoderm and mesoderm, since they cannot substitute for each other [9].
  • The PS1 integrin is expressed in epidermal cells and can mediate adhesion of the epidermal HAJs to the basement membrane [10].
  • PS1 expression is at the muscle ends and also in the long epidermal processes that connect the developing muscle fibers to their sites of attachment in the epidermis, while PS2 expression is restricted to the muscle ends [11].
  • To this end we have analyzed muscle attachments and neuromuscular junctions ultrastructurally in single or double mutant Drosophila embryos lacking PS1 integrin (alphaPS1betaPS), PS2 integrin (alphaPS2betaPS), and/or their potential extracellular ligand laminin A [10].
  • We have also examined the ability of alphaPS2 and alphaPS1 to maintain photoreceptor organization in the Drosophila retina [12].

Associations of mew with chemical compounds

  • Thus, another integrin in addition to PS1 appears to function on the dorsal wing surface [13].
  • The encoded alpha PS1 protein contains the cysteine pattern of the cleaved alpha integrins, three putative metal binding domains and shows the other characteristic features of alpha integrins [14].

Physical interactions of mew

  • On mature wing discs, each class of position-specific (PS) antibody binds nonuniformly with respect to the dorso-ventral compartment boundary, with PS1 antibodies binding primarily to dorsal cells and PS2 antibodies, to ventral cells [15].

Other interactions of mew


Analytical, diagnostic and therapeutic context of mew


  1. Distinct spatial and temporal functions for PS integrins during Drosophila wing morphogenesis. Brabant, M.C., Fristrom, D., Bunch, T.A., Brower, D.L. Development (1996) [Pubmed]
  2. Integrin-mediated short-term memory in Drosophila. Grotewiel, M.S., Beck, C.D., Wu, K.H., Zhu, X.R., Davis, R.L. Nature (1998) [Pubmed]
  3. Requirement for integrins during Drosophila wing development. Brower, D.L., Jaffe, S.M. Nature (1989) [Pubmed]
  4. Specific tracheal migration is mediated by complementary expression of cell surface proteins. Boube, M., Martin-Bermudo, M.D., Brown, N.H., Casanova, J. Genes Dev. (2001) [Pubmed]
  5. The Drosophila position-specific antigens are a family of cell surface glycoprotein complexes. Wilcox, M., Brown, N., Piovant, M., Smith, R.J., White, R.A. EMBO J. (1984) [Pubmed]
  6. Requirements for the cytoplasmic domain of the alphaPS1, alphaPS2 and betaPS integrin subunits during Drosophila development. Li, X., Graner, M.W., Williams, E.L., Roote, C.E., Bunch, T.A., Zusman, S. Development (1998) [Pubmed]
  7. A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development. Stark, K.A., Yee, G.H., Roote, C.E., Williams, E.L., Zusman, S., Hynes, R.O. Development (1997) [Pubmed]
  8. Evolution of the integrin alpha and beta protein families. Hughes, A.L. J. Mol. Evol. (2001) [Pubmed]
  9. Migration of the Drosophila primordial midgut cells requires coordination of diverse PS integrin functions. Martin-Bermudo, M.D., Alvarez-Garcia, I., Brown, N.H. Development (1999) [Pubmed]
  10. Absence of PS integrins or laminin A affects extracellular adhesion, but not intracellular assembly, of hemiadherens and neuromuscular junctions in Drosophila embryos. Prokop, A., Martín-Bermudo, M.D., Bate, M., Brown, N.H. Dev. Biol. (1998) [Pubmed]
  11. Development of the indirect flight muscle attachment sites in Drosophila: role of the PS integrins and the stripe gene. Fernandes, J.J., Celniker, S.E., VijayRaghavan, K. Dev. Biol. (1996) [Pubmed]
  12. Alternatively spliced forms of the Drosophila alphaPS2 subunit of integrin are sufficient for viability and can replace the function of the alphaPS1 subunit of integrin in the retina. Roote, C.E., Zusman, S. Development (1996) [Pubmed]
  13. Nonequivalent requirements for PS1 and PS2 integrin at cell attachments in Drosophila: genetic analysis of the alpha PS1 integrin subunit. Brower, D.L., Bunch, T.A., Mukai, L., Adamson, T.E., Wehrli, M., Lam, S., Friedlander, E., Roote, C.E., Zusman, S. Development (1995) [Pubmed]
  14. Cloning and characterization of alpha PS1, a novel Drosophila melanogaster integrin. Wehrli, M., DiAntonio, A., Fearnley, I.M., Smith, R.J., Wilcox, M. Mech. Dev. (1993) [Pubmed]
  15. Related cell-surface antigens expressed with positional specificity in Drosophila imaginal discs. Brower, D.L., Wilcox, M., Piovant, M., Smith, R.J., Reger, L.A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  16. Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2. Gotwals, P.J., Fessler, L.I., Wehrli, M., Hynes, R.O. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  17. Functions for PS integrins in tissue adhesion, migration, and shape changes during early embryonic development in Drosophila. Roote, C.E., Zusman, S. Dev. Biol. (1995) [Pubmed]
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