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Aslam, S.N. et al.

Use of recombinant human thyrotropin in a complicated case of metastatic papillary thyroid carcinoma.

OBJECTIVE: To describe a complicated case of metastatic papillary thyroid carcinoma and the use of recombinant human thyrotropin (thyroid-stimulating hormone) (rhTSH) in conjunction with treatment with radioactive iodine (131I). METHODS: We present a detailed case report and discuss the use of rhTSH in this setting. RESULTS: A 62-year-old Filipino man with a history of incompletely treated papillary thyroid cancer sought medical assistance in the emergency department because of weakness of the right upper extremity. Imaging studies showed a large mediastinal mass in association with C7 vertebral body erosion and spinal cord impingement. A cervical lymph node biopsy revealed papillary thyroid carcinoma, follicular variant. Further imaging studies disclosed widely metastatic disease. The patient subsequently had a complicated treatment course and received rhTSH in conjunction with 131I treatment. CONCLUSION: This unusual case demonstrates possible complications of metastatic papillary thyroid carcinoma along with innovations in treatment options, including the use of rhTSH to stimulate the uptake of radioiodine by thyroid cancer cells.[1]

References

Use of recombinant human thyrotropin in a complicated case of metastatic papillary thyroid carcinoma. Aslam, S.N., Daly, R.G. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. (2001) [Pubmed]

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