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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Friedman, J.I. et al.

Friedman, Adler, Temporini, Kemether, Harvey, White, Parrella, Davis,

Guanfacine treatment of cognitive impairment in schizophrenia.

Norepinephrine plays a significant role in the working memory functions of the prefrontal cortex by its actions at alpha-2a noradrenergic receptors. Guanfacine has demonstrated efficacy in reversing working memory deficits in non-human primate. In the present study the effect of guanfacine adjunctive treatment to neuroleptics on the cognitive performance of schizophrenic patients was investigated in a four week, placebo-controlled, double-blind, parallel design trial. The primary analyses revealed no significant differences between guanfacine and placebo treatment; however, exploratory non-parametric statistics revealed some significant and some trend differences between guanfacine and placebo on spatial working memory test performance and CPT reaction time in those subjects treated with atypical neuroleptics.[1]

References

Guanfacine treatment of cognitive impairment in schizophrenia. Friedman, J.I., Adler, D.N., Temporini, H.D., Kemether, E., Harvey, P.D., White, L., Parrella, M., Davis, K.L. Neuropsychopharmacology (2001) [Pubmed]

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