Chemical Compound Review:
Estulic N-(diaminomethylidene)-2- (2,6...
Synonyms:
Intuniv, GUANFACINE, Guanfacina, Guanfacinum, CHEMBL862, ...
- The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes. Arnsten, A.F., Cai, J.X., Goldman-Rakic, P.S. J. Neurosci. (1988)
- A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Scahill, L., Chappell, P.B., Kim, Y.S., Schultz, R.T., Katsovich, L., Shepherd, E., Arnsten, A.F., Cohen, D.J., Leckman, J.F. The American journal of psychiatry. (2001)
- Isradipine in essential hypertension: the Belgian General Practitioners' Study. De Keyser, P., Bouvé, J., Clement, D., Degraef, R., Meurant, J.P., Rorive, G., Van Thillo, J. Am. J. Med. (1989)
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- Effects of guanfacine monotherapy on blood pressure, heart rate, plasma renin activity, aldosterone, and catecholamines in hypertensive patients with chronic glomerulonephritis. Ikeda, T., Gomi, T., Yuhara, M., Sakurai, J., Nakayama, D. Clin. Pharmacol. Ther. (1988)
- Pharmacological options for the treatment of Tourette's disorder. Jiménez-Jiménez, F.J., García-Ruiz, P.J. Drugs (2001)
- Clonidine, but not guanfacine, impairs choice reaction time performance in young healthy volunteers. Jäkälä, P., Riekkinen, M., Sirviö, J., Koivisto, E., Riekkinen, P. Neuropsychopharmacology (1999)
- The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task. Avery, R.A., Franowicz, J.S., Studholme, C., van Dyck, C.H., Arnsten, A.F. Neuropsychopharmacology (2000)
- Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension. Sorkin, E.M., Heel, R.C. Drugs (1986)
- Identification of vascular postsynaptic alpha 1- and alpha 2-adrenoceptors in man. Jie, K., van Brummelen, P., Vermey, P., Timmermans, P.B., van Zwieten, P.A. Circ. Res. (1984)
- Noradrenergic modulation of space exploration in visual neglect. Malhotra, P.A., Parton, A.D., Greenwood, R., Husain, M. Ann. Neurol. (2006)
- The noradrenergic alpha2 agonist clonidine modulates behavioural and neuroanatomical correlates of human attentional orienting and alerting. Coull, J.T., Nobre, A.C., Frith, C.D. Cereb. Cortex (2001)
- Different responses of growth hormone secretion to guanfacine, bromocriptine, and thyrotropin-releasing hormone in acromegalic patients with pure growth hormone (GH)-containing and mixed GH/prolactin-containing pituitary adenomas. Lamberts, S.W., Klijn, J.G., van Vroonhoven, C.C., Stefanko, S.Z. J. Clin. Endocrinol. Metab. (1985)
- Behavioral and receptor binding analysis of the alpha 2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an alpha 2-adrenoceptor subtype. Arnsten, A.F., Leslie, F.M. Neuropharmacology (1991)
- Effects of clonidine and guanfacine in essential hypertension. Farsang, C., Varga, K., Vajda, L., Alföldi, S., Kapocsi, J. Clin. Pharmacol. Ther. (1984)
- Guanfacine kinetics in patients with hypertension. Weiss, Y.A., Lavene, D.L., Safar, M.E., Simon, A.C., Loria, Y., Georges, D.R., Milliez, P.L. Clin. Pharmacol. Ther. (1979)
- In summary: satellite symposium on central alpha-adrenergic blood pressure regulating mechanisms. Abrams, W.B. Hypertension (1984)
- The influence of renal function on plasma concentration, urinary excretion and antihypertensive effect of guanfacine. Kirch, W., Köhler, H., Braun, W., von Gizycki, C. Clinical pharmacokinetics. (1980)
- Binding characteristics of [3H]guanfacine to rat brain alpha-adrenoceptors. Comparison with [3H]clonidine. Timmermans, P.B., Schoop, A.M., van Zwieten, P.A. Biochem. Pharmacol. (1982)
- Antinociceptive actions of alpha 2-adrenoceptor agonists in the rat spinal cord: evidence for antinociceptive alpha 2-adrenoceptor subtypes and dissociation of antinociceptive alpha 2-adrenoceptors from cyclic AMP. Uhlén, S., Persson, M.L., Alari, L., Post, C., Axelsson, K.L., Wikberg, J.E. J. Neurochem. (1990)
- The effects of an alpha-2 adrenergic agonist, guanfacine, on rCBF in human cortex in normal controls and subjects with focal epilepsy. Swartz, B.E., Kovalik, E., Thomas, K., Torgersen, D., Mandelkern, M.A. Neuropsychopharmacology (2000)
- [3H]-MK 912 binding delineates two alpha 2-adrenoceptor subtypes in rat CNS one of which is identical with the cloned pA2d alpha 2-adrenoceptor. Uhlén, S., Xia, Y., Chhajlani, V., Felder, C.C., Wikberg, J.E. Br. J. Pharmacol. (1992)
- Renal alpha 2a/d-adrenoceptor subtype function: Wistar as compared to spontaneously hypertensive rats. Intengan, H.D., Smyth, D.D. Br. J. Pharmacol. (1997)
- The alpha-adrenoceptor control of adrenocorticotropin secretion in man. Lancranjan, I., Ohnhaus, E., Girard, J. J. Clin. Endocrinol. Metab. (1979)
- Clonidine-induced nitric oxide-dependent vasorelaxation mediated by endothelial alpha(2)-adrenoceptor activation. Figueroa, X.F., Poblete, M.I., Boric, M.P., Mendizábal, V.E., Adler-Graschinsky, E., Huidobro-Toro, J.P. Br. J. Pharmacol. (2001)
- Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors. Powell, S.B., Palomo, J., Carasso, B.S., Bakshi, V.P., Geyer, M.A. Psychopharmacology (Berl.) (2005)
- Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. Franowicz, J.S., Kessler, L.E., Borja, C.M., Kobilka, B.K., Limbird, L.E., Arnsten, A.F. J. Neurosci. (2002)
- The effect of intrathecal guanfacine and clonidine on the flexor reflex in rats with intact and sectioned sciatic nerves. Xu, X.J., Wikberg, J.E., Wiesenfeld-Hallin, Z. Eur. J. Pharmacol. (1993)
- The alpha-2A adrenoceptor agonist guanfacine improves sustained attention and reduces overactivity and impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder (ADHD). Sagvolden, T. Behavioral and brain functions : BBF (2006)
- Bradycardia during epidural anesthesia in a patient receiving guanfacine. Burney, R.G. Anesthesiology (1992)
- The bioavailability and pharmacokinetics of guanfacine after oral and intravenous administration to healthy volunteers. Carchman, S.H., Crowe, J.T., Wright, G.J. Journal of clinical pharmacology. (1987)