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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis.

Sepsis remains a significant clinical conundrum, and recent clinical trials with anticytokine therapies have produced disappointing results. Animal studies have suggested that increased lymphocyte apoptosis may contribute to sepsis-induced mortality. We report here that inhibition of thymocyte apoptosis by targeted adenovirus-induced thymic expression of human IL-10 reduced blood bacteremia and prevented mortality in sepsis. In contrast, systemic administration of an adenovirus expressing IL-10 was without any protective effect. Improvements in survival were associated with increases in Bcl-2 expression and reductions in caspase-3 activity and thymocyte apoptosis. These studies demonstrate that thymic apoptosis plays a critical role in the pathogenesis of sepsis and identifies a gene therapy approach for its therapeutic intervention.[1]

References

  1. Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis. Oberholzer, C., Oberholzer, A., Bahjat, F.R., Minter, R.M., Tannahill, C.L., Abouhamze, A., LaFace, D., Hutchins, B., Clare-Salzler, M.J., Moldawer, L.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
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