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Eisensehr, I. et al.

Eisensehr, Wetter, Linke, Noachtar, von Lindeiner, Gildehaus, Trenkwalder, Tatsch,

Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome.

Fourteen drug-naive and 11 levodopa-treated patients with idiopathic restless legs syndrome (RLS), and 10 controls age-matched to each RLS group separately were examined with polysomnography (PSG), [(123)I]-(N)-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane ((123)I-IPT) SPECT, and [(123)I]-(S)-2-hydroxy-3-iodo-6-methoxy-[(1-ethyl-2-pyrrolidinyl)methyl] benzamide ((123)I-IBZM) SPECT. Drug-naive and levodopa-treated patients with RLS and controls showed similar striatal dopamine transporter and dopamine D(2)-receptor binding, the latter declining with age. The authors conclude that striatal dopamine transporter and receptor density is normal in drug-naive and levodopa-treated patients with RLS.[1]

References

Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome. Eisensehr, I., Wetter, T.C., Linke, R., Noachtar, S., von Lindeiner, H., Gildehaus, F.J., Trenkwalder, C., Tatsch, K. Neurology (2001) [Pubmed]

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