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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways.

Cell cycle progression in mammalian cells is strictly regulated by both integrin- mediated adhesion to the extracellular matrix and by binding of growth factors to their receptors. This regulation is mediated by G1 phase cyclin-dependent kinases (CDKs), which are downstream of signaling pathways under the integrated control of both integrins and growth factor receptors. Recent advances demonstrate a surprisingly diverse array of integrin-dependent signals that are channeled into the regulation of the G1 phase CDKs. Regulation of cyclin D1 by the ERK pathway may provide a paradigm for understanding how cell adhesion can determine cell cycle progression.[1]


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