Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes.
The nemo-like kinase ( Nlk) connects the MAP kinase and Wnt signalling pathways. We have found that invertebrate (Caenorhabditis elegans, Drosophila melanogaster) and mammalian genomes (Mus musculus and Homo sapiens) each contain only a single functional Nlk gene. The mouse genome also harbours a transcriptionally silent processed Nlk pseudogene residing on chromosome 2. Thus, while genes encoding upstream (such as Wnts and frizzelds) and downstream (such as TCF/LEF) components of the Wnt signalling pathway have been extensively diversified during evolution, genes encoding components of the common core of the connecting signalling structure (such as beta-catenin, GSK beta and Nlk) have been maintained in single copies.[1]References
- Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes. Kortenjann, M., Wehrle, C., Nehls, M.C., Boehm, T. Gene (2001) [Pubmed]
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