Enoxaparin-associated severe retroperitoneal bleeding and abdominal compartment syndrome: a report of two cases.
OBJECTIVE: To describe a complication of low-molecular-weight heparin (enoxaparin) in the setting of critically ill patients. DESIGN: Case report. SETTING: The medical and surgical intensive care units of a tertiary care university teaching hospital. PATIENTS: Two adult patients receiving enoxaparin developed retroperitoneal hematoma and abdominal compartment syndrome. Both patients became anuric and required high-dose intravenous fluids and vasopressors to maintain blood pressure. INTERVENTION: Discontinuation of enoxaparin, followed by exploratory laparotomy and evacuation of the hematoma. MEASUREMENTS AND RESULTS: Immediate clinical improvement following evacuation of hematoma. CONCLUSIONS: High-risk patients receiving low-molecular-weight heparin should be identified and closely monitored to prevent serious bleeding complications.[1]References
- Enoxaparin-associated severe retroperitoneal bleeding and abdominal compartment syndrome: a report of two cases. Dabney, A., Bastani, B. Intensive care medicine. (2001) [Pubmed]
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