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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Laparotomy


High impact information on Laparotomy

  • We report here that in rat the beta-adrenoceptor antagonist (-)propranolol reduces or abolishes the rapid increase of immunoreactive beta-endorphin levels during some stress stimuli (footshock, passive avoidance, restraint) but not during others (ether, formalin, laparotomy) [6].
  • RESULTS: MuOR endocytosis induced by abdominal laparotomy was inhibited significantly by NMDA-receptor antagonists in nondenervated and denervated ileal segments, but not by the AMPA-receptor antagonist [7].
  • BACKGROUND: Wound complications that occur after closure of midline laparotomy remain challenging [8].
  • The aim of this study was to study arginine metabolism in the bile duct-ligated rat (BDL) after laparotomy [9].
  • Laparotomy significantly attenuates ethanol-induced gastric mucosal lesions in the rat [10].

Chemical compound and disease context of Laparotomy


Biological context of Laparotomy


Anatomical context of Laparotomy


Associations of Laparotomy with chemical compounds


Gene context of Laparotomy

  • An increase in the proportion of ovarian tumours negative for the hMLH1 subunit is observed in samples taken at second look laparotomy after chemotherapy (36%: 4/11), compared to untreated tumours (10%: 4/39) [27].
  • Concentrations of p53 were elevated in patients with advanced stage disease (P = 0.02) or poorly differentiated (P = 0.03), suboptimally debulked tumors (P = 0.02), as well as in patients who failed to respond to chemotherapy (P = 0.03), as assessed by computed tomography scanning, serum CA125 determination, and second-look laparotomy [28].
  • RESULTS: Production of TNF-alpha and IL-6 was similar in laparoscopy, laparotomy, and control groups [29].
  • In the subgroup of patients who underwent explorative laparotomy COX-2-positive cases showed a shorter overall survival (P = 0.049) [30].
  • The role of CRF1 receptors for sympathetic nervous response to laparotomy in anesthetized rats [31].

Analytical, diagnostic and therapeutic context of Laparotomy


  1. Failure of second-look laparotomy to influence survival in epithelial ovarian cancer. Luesley, D., Lawton, F., Blackledge, G., Hilton, C., Kelly, K., Rollason, T., Wade-Evans, T., Jordan, J., Fielding, J., Latief, T. Lancet (1988) [Pubmed]
  2. Ectopic pregnancy diagnosed by measurement of HCG but not laparotomy. Phipps, J.H., Naftalin, N.J. Lancet (1986) [Pubmed]
  3. Pathogenesis of precirrhotic portal hypertension in alcohol-fed baboons. Miyakawa, H., Iida, S., Leo, M.A., Greenstein, R.J., Zimmon, D.S., Lieber, C.S. Gastroenterology (1985) [Pubmed]
  4. Simultaneous resistance to metronidazole, co-amoxiclav, and imipenem in clinical isolate of Bacteroides fragilis. Turner, P., Edwards, R., Weston, V., Gazis, A., Ispahani, P., Greenwood, D. Lancet (1995) [Pubmed]
  5. Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. Peters, G.J., van der Wilt, C.L., van Groeningen, C.J., Smid, K., Meijer, S., Pinedo, H.M. J. Clin. Oncol. (1994) [Pubmed]
  6. Beta-adrenoceptor activation mediates stress-induced secretion of beta-endorphin-related peptides from intermediate but not anterior pituitary. Berkenbosch, F., Tilders, F.J., Vermes, I. Nature (1983) [Pubmed]
  7. N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery. Patierno, S., Zellalem, W., Ho, A., Parsons, C.G., Lloyd, K.C., Tonini, M., Sternini, C. Gastroenterology (2005) [Pubmed]
  8. Influence of abdominal-wound closure technique on complications after surgery: a randomised study. Niggebrugge, A.H., Trimbos, J.B., Hermans, J., Steup, W.H., Van De Velde, C.J. Lancet (1999) [Pubmed]
  9. Arginine deficiency in bile duct-ligated rats after surgery: the role of plasma arginase and gut endotoxin restriction. Houdijk, A.P., Teerlink, T., Visser, J.J., van Lambalgen, A.A., van Leeuwen, P.A. Gastroenterology (1997) [Pubmed]
  10. Laparotomy-induced gastric protection against ethanol injury is mediated by capsaicin-sensitive sensory neurons. Yonei, Y., Holzer, P., Guth, P.H. Gastroenterology (1990) [Pubmed]
  11. Vinblastine, bleomycin, and methotrexate chemotherapy plus extended-field radiotherapy in early, favorably presenting, clinically staged Hodgkin's patients: the Gruppo Italiano per lo Studio dei Linfomi Experience. Gobbi, P.G., Pieresca, C., Frassoldati, A., Carotenuto, M., Di Renzo, N., La Sala, A., Berté, R., Avanzini, P., Federico, M., Silingardi, V., Ascari, E. J. Clin. Oncol. (1996) [Pubmed]
  12. Effect of intra-abdominal bupivacaine instillation on postoperative colonic motility. Rimbäck, G., Cassuto, J., Faxén, A., Högström, S., Wallin, G., Tollesson, P.O. Gut (1986) [Pubmed]
  13. Impact of gas(less) laparoscopy and laparotomy on peritoneal tumor growth and abdominal wall metastases. Bouvy, N.D., Marquet, R.L., Jeekel, H., Bonjer, H.J. Ann. Surg. (1996) [Pubmed]
  14. Gallium scanning for the detection of abdominal abscesses. Forgacs, P., Wahner, H.W., Keys, T.F., Van Scoy, R.E. Am. J. Med. (1978) [Pubmed]
  15. Effect of portosystemic shunting on PGI2 and glucagon levels in humans. Sitzmann, J.V., Campbell, K.A., Wu, Y., Cameron, J.L. Ann. Surg. (1993) [Pubmed]
  16. Effect of Lactobacillus johnsonii La1 and antioxidants on intestinal flora and bacterial translocation in rats with experimental cirrhosis. Chiva, M., Soriano, G., Rochat, I., Peralta, C., Rochat, F., Llovet, T., Mirelis, B., Schiffrin, E.J., Guarner, C., Balanzó, J. J. Hepatol. (2002) [Pubmed]
  17. Metoclopramide: a novel adjunct for improving cardiac and hepatocellular functions after trauma-hemorrhage. Jarrar, D., Wang, P., Song, G.Y., Knöferl, M.W., Cioffi, W.G., Bland, K.I., Chaudry, I.H. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  18. Randomized comparison of polyglycolic acid and polyglyconate sutures for abdominal fascial closure after laparotomy in patients with suspected impaired wound healing. Hewin, D.F. The British journal of surgery. (1995) [Pubmed]
  19. Gender differences in small intestinal perfusion following trauma hemorrhage: the role of endothelin-1. Ba, Z.F., Shimizu, T., Szalay, L., Bland, K.I., Chaudry, I.H. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  20. In vitro fertilization with concurrent pelvic reconstructive surgery. Roh, S.I., Dodds, W.G., Park, J.M., Awadalla, S.G., Friedman, C.I., Kim, M.H. Fertil. Steril. (1988) [Pubmed]
  21. Metabolism of testosterone in previable human fetuses. Stern, M.D., Ling, W., Coutts, J.R., MacNaughton, M.C., Solomon, S. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
  22. Circadian and seasonal variation in human preovulatory follicular fluid melatonin concentration. Rönnberg, L., Kauppila, A., Leppäluoto, J., Martikainen, H., Vakkuri, O. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  23. Determination of pefloxacin concentration in mesenteric lymph nodes by high-performance chromatography. Munera, M.I., Cuesta, F., Abadia, A., Vasquez, J., Restrepo, M. Antimicrob. Agents Chemother. (1994) [Pubmed]
  24. Pentoxifylline improves tissue oxygenation following anesthesia and operation. Soliman, M.H., O'Neal, K., Waxman, K. Crit. Care Med. (1987) [Pubmed]
  25. Effect of low-dose heparin prophylaxis on arterial oxygen tension after high laparotomy. Lahnborg, G., Lagergren, H., Hedenstierna, G. Lancet (1976) [Pubmed]
  26. Neoadjuvant therapy of high-risk gastric cancer: a phase II trial of preoperative FAMTX and postoperative intraperitoneal fluorouracil-cisplatin plus intravenous fluorouracil. Kelsen, D., Karpeh, M., Schwartz, G., Gerdes, H., Lightdale, C., Botet, J., Lauers, G., Klimstra, D., Huang, Y., Saltz, L., Quan, V., Brennan, M. J. Clin. Oncol. (1996) [Pubmed]
  27. hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents. Brown, R., Hirst, G.L., Gallagher, W.M., McIlwrath, A.J., Margison, G.P., van der Zee, A.G., Anthoney, D.A. Oncogene (1997) [Pubmed]
  28. Evidence for a dose-response effect between p53 (but not p21WAF1/Cip1) protein concentrations, survival, and responsiveness in patients with epithelial ovarian cancer treated with platinum-based chemotherapy. Levesque, M.A., Katsaros, D., Massobrio, M., Genta, F., Yu, H., Richiardi, G., Fracchioli, S., Durando, A., Arisio, R., Diamandis, E.P. Clin. Cancer Res. (2000) [Pubmed]
  29. Laparoscopic surgery and Kupffer cell activation. Vittimberga, F.J., Nolan, B., Perugini, R.A., Spector, L., Callery, M.P. Surgical endoscopy. (2000) [Pubmed]
  30. Cyclooxygenase-2 (COX-2), epidermal growth factor receptor (EGFR), and Her-2/neu expression in ovarian cancer. Ferrandina, G., Ranelletti, F.O., Lauriola, L., Fanfani, F., Legge, F., Mottolese, M., Nicotra, M.R., Natali, P.G., Zakut, V.H., Scambia, G. Gynecol. Oncol. (2002) [Pubmed]
  31. The role of CRF1 receptors for sympathetic nervous response to laparotomy in anesthetized rats. Uetsuki, N., Segawa, H., Mayahara, T., Fukuda, K. Brain Res. (2005) [Pubmed]
  32. Pancreatic hormone profiles and metabolism posthepatectomy in the dog. Evidence for a hepatotrophic role of insulin, glucagon, and pancreatic polypeptide. Cohen, D.M., Jaspan, J.B., Polonsky, K.S., Lever, E.G., Moossa, A.R. Gastroenterology (1984) [Pubmed]
  33. A randomized trial comparing single-agent carboplatin with carboplatin followed by radiotherapy for advanced ovarian cancer: a North Thames Ovary Group study. Lambert, H.E., Rustin, G.J., Gregory, W.M., Nelstrop, A.E. J. Clin. Oncol. (1993) [Pubmed]
  34. Hodgkin's disease in childhood and adolescence: results of chemotherapy-radiotherapy in clinical stages IA-IIB. Cramer, P., Andrieu, J.M. J. Clin. Oncol. (1985) [Pubmed]
  35. Laparoscopy and laparoscopic ultrasonography avoid exploratory laparotomy in patients with hepatocellular carcinoma. Lo, C.M., Lai, E.C., Liu, C.L., Fan, S.T., Wong, J. Ann. Surg. (1998) [Pubmed]
  36. Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats. De Winter, B.Y., Boeckxstaens, G.E., De Man, J.G., Moreels, T.G., Schuurkes, J.A., Peeters, T.L., Herman, A.G., Pelckmans, P.A. Gut (1999) [Pubmed]
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