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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

Myosin-1c (also known as myosin-Ibeta) has been proposed to mediate the slow component of adaptation by hair cells, the sensory cells of the inner ear. To test this hypothesis, we mutated tyrosine-61 of myosin-1c to glycine, conferring susceptibility to inhibition by N(6)-modified ADP analogs. We expressed the mutant myosin-1c in utricular hair cells of transgenic mice, delivered an ADP analog through a whole-cell recording pipette, and found that the analog rapidly blocked adaptation to positive and negative deflections in transgenic cells but not in wild-type cells. The speed and specificity of inhibition suggests that myosin-1c participates in adaptation in hair cells.[1]

References

  1. A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Holt, J.R., Gillespie, S.K., Provance, D.W., Shah, K., Shokat, K.M., Corey, D.P., Mercer, J.A., Gillespie, P.G. Cell (2002) [Pubmed]
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