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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Regulated expression of Wnts and Frizzleds at specific stages of follicular development in the rodent ovary.

Wnt ligands and Frizzled ( Fz) G protein-coupled receptors impact cell fate, including embryonic development of the ovary. Because the role of these regulatory molecules during follicular development in the adult is not known, an RT-PCR survey was done. Wnt-4, Fz-4, and Fz-1 were among the transcripts detected, and each exhibited a specific pattern of expression. Fz-1 mRNA was low in preovulatory follicles of PMSG-treated mice but was increased within 4-12 h after an ovulatory surge of human CG. By in situ analysis, Fz-1 transcripts increased first in the theca cells and then in the granulosa cells of ovulating follicles but were low in corpora lutea. In contrast, Wnt-4, a critical factor in early ovarian development, was expressed in small preantral follicles. In addition, Wnt-4 was detected in preovulatory follicles and exhibited high levels in corpora lutea. A potential receptor for Wnt-4 in corpora lutea is Fz-4 that was also elevated in this tissue. Although Wnt-4 has been shown to function downstream of the PR in other tissues, Wnt-4 was not altered in follicles of PR-null mice that fail to ovulate. Rather expression of Fz-1 was lower in ovaries of PR knockout mice, compared with normal littermates. Thus, specific Wnt/ Fz are expressed at distinct stages of follicular development, suggesting multiple functions for this signaling pathway in the ovary.[1]


  1. Regulated expression of Wnts and Frizzleds at specific stages of follicular development in the rodent ovary. Hsieh, M., Johnson, M.A., Greenberg, N.M., Richards, J.S. Endocrinology (2002) [Pubmed]
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