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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila.

Two types of transgene silencing were found for the Alcohol dehydrogenase ( Adh) transcription unit. Transcriptional gene silencing (TGS) is Polycomb dependent and occurs when Adh is driven by the white eye color gene promoter. Full-length Adh transgenes are silenced posttranscriptionally at high copy number or by a pulsed increase over a threshold. The posttranscriptional gene silencing (PTGS) exhibits molecular hallmarks typical of RNA interference (RNAi), including the production of 21--25 bp length sense and antisense RNAs homologous to the silenced RNA. Mutations in piwi, which belongs to a gene family with members required for RNAi, block PTGS and one aspect of TGS, indicating a connection between the two types of silencing.[1]

References

  1. RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Pal-Bhadra, M., Bhadra, U., Birchler, J.A. Mol. Cell (2002) [Pubmed]
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