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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Analysis of the role of RecQ helicases in RNAi in mammals.

The identity of mammalian genes involved in RNA interference (RNAi), the targeted sequence-specific mRNA degradation by double-stranded RNA (dsRNA), is poorly defined. Here we report the analysis of mice with null mutations of Wrn, Blm, and RecQ1 genes that are related to Mut-7 and Qde3, two genes essential for RNAi in Caenorhabditis elegans and quelling in Neurospora, respectively. Our results suggest that Wrn, Blm, and RecQ1 are not involved in sequence-specific mRNA degradation in mammals in response to dsRNA, suggesting potential differences in the mammalian RNAi pathway.[1]


  1. Analysis of the role of RecQ helicases in RNAi in mammals. Stein, P., Svoboda, P., Stumpo, D.J., Blackshear, P.J., Lombard, D.B., Johnson, B., Schultz, R.M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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