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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Methotrexate leukoencephalopathy presenting as Klüver-Bucy syndrome and uncinate seizures.

Methotrexate causes several biochemical changes that impact the nervous system. The neurotoxicity usually affects the cerebral white matter, causing a leukoencephalopathy that can be chronic and progressive with cognitive decline. A 15-year-old male developed olfactory seizures and behavioral abnormalities (hypersexuality, placidity, and memory disturbances) compatible with partial Klüver-Bucy syndrome after treatment for central nervous system leukemia with intraventricular methotrexate. A magnetic resonance imaging study revealed evidence of white matter disease affecting both temporal lobes. A brain biopsy revealed a necrotizing encephalopathy compatible with methotrexate-related white matter injury. It may be prudent to verify normal cerebrospinal fluid dynamics before the administration of intraventricular methotrexate in children with a history of central nervous system leukemia.[1]

References

  1. Methotrexate leukoencephalopathy presenting as Klüver-Bucy syndrome and uncinate seizures. Antunes, N.L., Souweidane, M.M., Lis, E., Rosenblum, M.K., Steinherz, P.G. Pediatric neurology. (2002) [Pubmed]
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