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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Four pregnancies in two patients with essential thrombocythaemia--a case report.

INTRODUCTION: We report our experience of 4 pregnancies in 2 patients who had essential thrombocythaemia (ET). CLINICAL PICTURE: Two patients with ET were managed with a variety of therapeutic approaches including the use of low-dose aspirin, plateletpheresis, hydroxyurea and alpha-interferon in the course of their 4 pregnancies. TREATMENT AND OUTCOME: One patient had 2 successful pregnancies despite having platelet counts in excess of 1000 x 10(9)/L antenatally. The second patient had an intrauterine fetal death during the third trimester of her first pregnancy but had a successful second pregnancy. CONCLUSION AND CLINICAL IMPLICATIONS: Management of ET in pregnancy is still very much individualized. The impact of various treatment modalities on the pregnancy outcome remains to be proven but a favourable pregnancy outcome is possible.[1]


  1. Four pregnancies in two patients with essential thrombocythaemia--a case report. Koh, L.P., Devendra, K., Tien, S.L. Ann. Acad. Med. Singap. (2002) [Pubmed]
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