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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mechanisms of TNF receptor-associated factor (TRAF) regulation in B lymphocytes.

A key component of signaling by members of the tumor necrosis factor receptor (TNF-R) family is interaction with the cytoplasmic adapter proteins known as TRAFs. Several proteins encoded by microbes also interact with TRAFs. A notable example is the CD40 receptor, expressed on antigen presenting cells and providing key activation signals in T cell-dependent B cell activation. CD40 signals to B cells are mimicked by a constitutively active viral protein produced by the Epstein-Barr virus. For each of these receptors, multiple mechanisms of TRAF regulation contribute to signal transduction and the ultimate effect on the B cell. Recent findings concerning these regulatory mechanisms are summarized in this overview.[1]

References

  1. Mechanisms of TNF receptor-associated factor (TRAF) regulation in B lymphocytes. Bishop, G.A., Hostager, B.S., Brown, K.D. J. Leukoc. Biol. (2002) [Pubmed]
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