The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Traf1  -  TNF receptor-associated factor 1

Mus musculus

Synonyms: 4732496E14Rik
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Traf1


High impact information on Traf1


Biological context of Traf1


Anatomical context of Traf1

  • TNF Receptor-Associated Factor 2-Dependent Canonical Pathway Is Crucial for the Development of Peyer's Patches [10].

Associations of Traf1 with chemical compounds

  • In addition we show that TRAF1 mRNA is not expressed in non-stimulated lymphocytes but can be induced upon activation with different stimuli, including anti-CD3, anti-IgM, anti-CD40 antibodies, LPS, or a combination of phorbol-12-myristate-13-acetate and ionomycin [9].

Other interactions of Traf1

  • Despite relatively mild lung injury, intratracheal TNF-alpha-treated TRAF1-/- mice exhibited marked liver injury with an approximate fivefold increase in serum liver enzyme levels as compared to wild-type mice [11].

Analytical, diagnostic and therapeutic context of Traf1


  1. Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. Kim, N., Kadono, Y., Takami, M., Lee, J., Lee, S.H., Okada, F., Kim, J.H., Kobayashi, T., Odgren, P.R., Nakano, H., Yeh, W.C., Lee, S.K., Lorenzo, J.A., Choi, Y. J. Exp. Med. (2005) [Pubmed]
  2. TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice. Zapata, J.M., Krajewska, M., Morse, H.C., Choi, Y., Reed, J.C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family. Ordway, D., Henao-Tamayo, M., Orme, I.M., Gonzalez-Juarrero, M. J. Immunol. (2005) [Pubmed]
  4. Multiple carboxyl-terminal regions of the EBV oncoprotein, latent membrane protein 1, cooperatively regulate signaling to B lymphocytes via TNF receptor-associated factor (TRAF)-dependent and TRAF-independent mechanisms. Busch, L.K., Bishop, G.A. J. Immunol. (2001) [Pubmed]
  5. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Rothe, M., Sarma, V., Dixit, V.M., Goeddel, D.V. Science (1995) [Pubmed]
  6. TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. Tsitsikov, E.N., Laouini, D., Dunn, I.F., Sannikova, T.Y., Davidson, L., Alt, F.W., Geha, R.S. Immunity (2001) [Pubmed]
  7. CD27 is required for generation and long-term maintenance of T cell immunity. Hendriks, J., Gravestein, L.A., Tesselaar, K., van Lier, R.A., Schumacher, T.N., Borst, J. Nat. Immunol. (2000) [Pubmed]
  8. Mechanisms of TNF receptor-associated factor (TRAF) regulation in B lymphocytes. Bishop, G.A., Hostager, B.S., Brown, K.D. J. Leukoc. Biol. (2002) [Pubmed]
  9. Structure of the murine TRAF1 gene. Dunn, I.F., Geha, R.S., Tsitsikov, E.N. Mol. Immunol. (1999) [Pubmed]
  10. TNF Receptor-Associated Factor 2-Dependent Canonical Pathway Is Crucial for the Development of Peyer's Patches. Piao, J.H., Yoshida, H., Yeh, W.C., Doi, T., Xue, X., Yagita, H., Okumura, K., Nakano, H. J. Immunol. (2007) [Pubmed]
  11. Acute tumor necrosis factor-alpha-induced liver injury in the absence of tumor necrosis factor receptor-associated factor 1 gene expression. Pryhuber, G.S., Huyck, H.L., Roper, J.M., Cornejo, J., O'Reilly, M.A., Pierce, R.H., Tsitsikov, E.N. Am. J. Pathol. (2005) [Pubmed]
  12. Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development. Masson, R., Régnier, C.H., Chenard, M.P., Wendling, C., Mattei, M.G., Tomasetto, C., Rio, M.C. Mech. Dev. (1998) [Pubmed]
WikiGenes - Universities