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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma.

Paraneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 without evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging and at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone.[1]

References

  1. Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma. Vernino, S., Tuite, P., Adler, C.H., Meschia, J.F., Boeve, B.F., Boasberg, P., Parisi, J.E., Lennon, V.A. Ann. Neurol. (2002) [Pubmed]
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