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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Intracranial administration of transforming growth factor-beta3 increases fat oxidation in rats.

The effects of intracranial transforming growth factor (TGF)-beta3 on spontaneous motor activity and energy metabolism were examined in rats. After injection of TGF-beta3 into the cisterna magna of the rat, spontaneous motor activity decreased significantly for 1 h. The intracranial injection of TGF-beta3 produced an immediate decrease in respiratory exchange ratio (RER). No significant changes were observed in energy expenditure. TGF-beta3 induced a significant increase in total fat oxidation and a decrease in total carbohydrate oxidation. Furthermore, the serum substrates associated with fat metabolism were significantly altered in rats injected with TGF-beta3. Both lipoprotein lipase activity in skeletal muscle and the concentration of serum ketone bodies increased, suggesting that the increase in fat oxidation caused by TGF-beta3 may have occurred in the liver and muscle. Intracranial injection of TGF-beta3 appeared to evoke a switch in the energy substrates accessed in energy expenditure. These results suggest that the release of TGF-beta3 in the brain by exercise is a signal for regulating energy consumption.[1]


  1. Intracranial administration of transforming growth factor-beta3 increases fat oxidation in rats. Yamazaki, H., Arai, M., Matsumura, S., Inoue, K., Fushiki, T. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
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